Regulatory Network in Protein Phosphorylation
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Substrate: BTK

Description: Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK).

Synonyms: AGMX1, ATK, BPK

Ensembl ID: ENSG00000010671

UniprotKB/SwissProt: BTK_HUMAN (Q06187)

Function: Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity).
PDB:1AWW
Protein Domain and Phosphorylation Sites: