Regulatory Network in Protein Phosphorylation
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Substrate: BTK

Description: Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK).

Synonyms: AGMX1, ATK, BPK

Ensembl ID: ENSG00000010671

UniprotKB/SwissProt: BTK_HUMAN (Q06187)

Function: Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity).
PDB:1AWW
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BTK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BTKBTK_HUMANY40HKLSY Y EYDFE 12.49% Swiss-Prot 55.0 (Similarity)View   
2BTKBTK_HUMANS180LKPGS S HRKTK 32.97%PKCb HPRD:02248(in vitro;in vivo)  ViewAnalyzing
3BTKBTK_HUMANY223KVVAL Y DYMPM 8.69%ABL1 Phospho.ELM 7.0  ViewAnalyzing
4BTKBTK_HUMANY223KVVAL Y DYMPM 8.69%TEC HPRD:02248(in vitro;in vivo)  ViewAnalyzing
5BTKBTK_HUMANY223KVVAL Y DYMPM 8.69%BTK Phospho.ELM 7.0  ViewAnalyzing
6BTKBTK_HUMANY223KVVAL Y DYMPM 8.69%BTK HPRD:02248(in vitro;in vivo)  ViewAnalyzing
7BTKBTK_HUMANY223KVVAL Y DYMPM 8.69%ITK HPRD:02248(in vitro;in vivo)  ViewAnalyzing
8BTKBTK_HUMANY223KVVAL Y DYMPM 8.69%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
9BTKBTK_HUMANY223KVVAL Y DYMPM 8.69%ABL1 HPRD:02248(in vitro;in vivo)  ViewAnalyzing
10BTKBTK_HUMANY344TPQSQ Y YLAEK 12.99% Swiss-Prot 55.0 (Similarity)View   
11BTKBTK_HUMANY551VLDDE Y TSSVG 20.93%Lyn Phospho.ELM 7.0  ViewAnalyzing
12BTKBTK_HUMANY551VLDDE Y TSSVG 20.93%LYN HPRD:02248(in vitro;in vivo)  ViewAnalyzing
13BTKBTK_HUMANY551VLDDE Y TSSVG 20.93%SYK HPRD:02248(in vitro;in vivo)  ViewAnalyzing
14BTKBTK_HUMANY551VLDDE Y TSSVG 20.93%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
15BTKBTK_HUMANY551VLDDE Y TSSVG 20.93%BTK Phospho.ELM 7.0  ViewAnalyzing
16BTKBTK_HUMANY617QGLRL Y RPHLA 18.70% HPRD:02248(in vitro)View