Regulatory Network in Protein Phosphorylation
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Substrate: CASP9

Description: Caspase-9 precursor (EC 3.4.22.62) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10].

Synonyms: MCH6

Ensembl ID: ENSG00000132906

UniprotKB/SwissProt: CASP9_HUMAN (P55211)

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1JXQ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CASP9

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CASP9CASP9_HUMANT125VLRPE T PRPVD 27.55%MAP2K2 HPRD:03756(in vitro;in vivo)  ViewAnalyzing
2CASP9CASP9_HUMANT125VLRPE T PRPVD 27.55%Erk1 HPRD:03756(in vitro;in vivo)  ViewAnalyzing
3CASP9CASP9_HUMANT125VLRPE T PRPVD 27.55%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
4CASP9CASP9_HUMANT125VLRPE T PRPVD 27.55%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
5CASP9CASP9_HUMANT125VLRPE T PRPVD 27.55%MAP2K1 HPRD:03756(in vitro;in vivo)  ViewAnalyzing
6CASP9CASP9_HUMANT125VLRPE T PRPVD 27.55%Erk2 HPRD:03756(in vitro;in vivo)  ViewAnalyzing
7CASP9CASP9_HUMANS144VGALE S LRGNA 24.98%PKCz HPRD:03756(in vitro;in vivo)  ViewAnalyzing
8CASP9CASP9_HUMANS144VGALE S LRGNA 24.98%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing
9CASP9CASP9_HUMANY153NADLA Y ILSME 15.08%ABL1 Phospho.ELM 7.0  ViewAnalyzing
10CASP9CASP9_HUMANY153NADLA Y ILSME 15.08%ABL1 HPRD:03756(in vitro;in vivo)  ViewAnalyzing
11CASP9CASP9_HUMANS183RTRTG S NIDCE 29.96%AKT1 HPRD:03756(in vitro)  ViewAnalyzing
12CASP9CASP9_HUMANS183RTRTG S NIDCE 29.96% Phospho.ELM 7.0View   
13CASP9CASP9_HUMANS196RRRFS S LHFMV 24.13%AKT1 HPRD:03756(in vitro)  ViewAnalyzing
14CASP9CASP9_HUMANS196RRRFS S LHFMV 24.13%AKT_group Phospho.ELM 7.0 ViewAnalyzing