|Description: Caspase-9 precursor (EC 18.104.22.168) (CASP-9) (ICE-like apoptoticprotease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35;Caspase-9 subunit p10].|
Ensembl ID: ENSG00000132906
UniprotKB/SwissProt: CASP9_HUMAN (P55211)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: