Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase ABL2(ARG)]
Substrate: CBL

Description: E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55).

Synonyms: CBL2, RNF55

Ensembl ID: ENSG00000110395

UniprotKB/SwissProt: CBL_HUMAN (P22681)

Function: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:1B47
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CBL

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CBLCBL_HUMANY337FREGF Y LFPDG 20.49% Phospho.ELM 7.0View   
2CBLCBL_HUMANY368VTQEQ Y ELYCE 13.72% Phospho.ELM 7.0View   
3CBLCBL_HUMANY371EQYEL Y CEMGS 3.71%EGFR Phospho.ELM 7.0