Regulatory Network in Protein Phosphorylation
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Substrate: CDK5

Description: Cell division protein kinase 5 (EC 2.7.11.22) (Cyclin-dependent kinase5) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)(Serine/threonine-protein kinase PSSALRE).

Ensembl ID: ENSG00000164885

UniprotKB/SwissProt: CDK5_HUMAN (Q00535)

Function: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity).
PDB:1H4L
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDK5

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDK5CDK5_HUMANT14KIGEG T YGTVF 17.93% Swiss-Prot 55.0 (Similarity)View   
2CDK5CDK5_HUMANY15IGEGT Y GTVFK 22.96%ABL1  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
3CDK5CDK5_HUMANY15IGEGT Y GTVFK 22.96%FYN HPRD:00449(in vivo)  ViewAnalyzing
4CDK5CDK5_HUMANY15IGEGT Y GTVFK 22.96%ABL1 HPRD:00449(in vivo)  ViewAnalyzing
5CDK5CDK5_HUMANY15IGEGT Y GTVFK 22.96%ABL1 Phospho.ELM 7.0  ViewAnalyzing
6CDK5CDK5_HUMANS159PVRCY S AEVVT 22.91% Swiss-Prot 55.0 (Similarity)View   
7CDK5CDK5_HUMANS159PVRCY S AEVVT 22.91%CK1_group Phospho.ELM 7.0 ViewAnalyzing
8CDK5CDK5_HUMANS159PVRCY S AEVVT 22.91%CK1d HPRD:00449(in vitro)  ViewAnalyzing