Regulatory Network in Protein Phosphorylation
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Substrate: DCX

Description: Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X)(Doublin).

Synonyms: DBCN, LISX

Ensembl ID: ENSG00000077279

UniprotKB/SwissProt: DCX_HUMAN (O43602)

Function: Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:1MJD
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DCX

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DCXDCX_HUMANT56DERDK T SRNMR 36.89%PKC_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
2DCXDCX_HUMANS70MNGLP S PTHSA 47.69%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
3DCXDCX_HUMANS89TLQAL S NEKKA 46.06% Phospho.ELM 7.0View   
4DCXDCX_HUMANY112FKGIV Y AVSSD 10.20%ABL  Swiss-Prot 55.0 (Potential) ViewAnalyzing
5DCXDCX_HUMANY112FKGIV Y AVSSD 10.20% Phospho.ELM 7.0View   
6DCXDCX_HUMANS116VYAVS S DRFRS 26.63%PKC_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
7DCXDCX_HUMANS132ADLTR S LSDNI 27.30%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
8DCXDCX_HUMANS152YTIDG S RKIGS 27.01%PKC_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
9DCXDCX_HUMANS157SRKIG S MDELE 26.91%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
10DCXDCX_HUMANS307AQDDF S LDENE 41.74%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
11DCXDCX_HUMANS329AGPKA S PTPQK 35.12%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
12DCXDCX_HUMANT331PKASP T PQKTS 35.54%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
13DCXDCX_HUMANS336TPQKT S AKSPG 40.51%PKC_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
14DCXDCX_HUMANS339KTSAK S PGPMR 34.50% Phospho.ELM 7.0View   
15DCXDCX_HUMANS339KTSAK S PGPMR 34.50%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
16DCXDCX_HUMANS346GPMRR S KSPAD 27.41% Swiss-Prot 55.0 (Similarity)View   
17DCXDCX_HUMANS348MRRSK S PADSA 26.94%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
18DCXDCX_HUMANS348MRRSK S PADSA 26.94%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
19DCXDCX_HUMANS357SANGT S SSQLS 29.41% HPRD:02127(in vitro)View   
20DCXDCX_HUMANS359NGTSS S QLSTP 34.60% Swiss-Prot 55.0 (Similarity)View   
21DCXDCX_HUMANT363SSQLS T PKSKQ 43.24%PKC_group Swiss-Prot 55.0 (Potential) ViewAnalyzing
22DCXDCX_HUMANT363SSQLS T PKSKQ 43.24%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
23DCXDCX_HUMANT363SSQLS T PKSKQ 43.24%MAPK_group Swiss-Prot 55.0 (Potential) ViewAnalyzing
24DCXDCX_HUMANS369PKSKQ S PISTP 28.12%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
25DCXDCX_HUMANS369PKSKQ S PISTP 28.12%MAPK_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
26DCXDCX_HUMANS372KQSPI S TPTSP 31.55% Swiss-Prot 55.0 View   
27DCXDCX_HUMANS372KQSPI S TPTSP 31.55% Phospho.ELM 7.0View   
28DCXDCX_HUMANT373QSPIS T PTSPG 31.16%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
29DCXDCX_HUMANT373QSPIS T PTSPG 31.16%MAPK_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
30DCXDCX_HUMANS376ISTPT S PGSLR 28.59%MAPK_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
31DCXDCX_HUMANS376ISTPT S PGSLR 28.59%CDK5 HPRD:02127(in vitro)  ViewAnalyzing
32DCXDCX_HUMANS379PTSPG S LRKHK 28.52%PKC_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
33DCXDCX_HUMANS391LYLPL S LDDSD 28.01%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
34DCXDCX_HUMANS397LDDSD S LGDSM 37.90%CK2_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing