Regulatory Network in Protein Phosphorylation
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Substrate: JAK2

Description: Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

Ensembl ID: ENSG00000096968

UniprotKB/SwissProt: JAK2_HUMAN (O60674)

Function: Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity).
PDB:2B7A
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of JAK2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1JAK2JAK2_HUMANY201TPLAI Y NSISY 9.39%JAK2 HPRD:00993(in vivo)  ViewAnalyzing
2JAK2JAK2_HUMANY206YNSIS Y KTFLP 16.63%JAK2 HPRD:00993(in vitro)  ViewAnalyzing
3JAK2JAK2_HUMANY221AKIQD Y HILTR 3.71%JAK2 HPRD:00993(in vitro;in vivo)  ViewAnalyzing
4JAK2JAK2_HUMANY570REVGD Y GQLHE 10.80% Swiss-Prot 55.0 (Similarity)View   
5JAK2JAK2_HUMANY570REVGD Y GQLHE 10.80%JAK2 HPRD:00993(in vitro;in vivo)  ViewAnalyzing
6JAK2JAK2_HUMANY570REVGD Y GQLHE 10.80% Phospho.ELM 7.0View   
7JAK2JAK2_HUMANY813LFTPD Y ELLTE 15.07% Phospho.ELM 7.0View   
8JAK2JAK2_HUMANY813LFTPD Y ELLTE 15.07%JAK2 HPRD:00993(in vivo)  ViewAnalyzing
9JAK2JAK2_HUMANY1007PQDKE Y YKVKE 17.83%autocatalysis Swiss-Prot 55.0 (Similarity) ViewAnalyzing
10JAK2JAK2_HUMANY1007PQDKE Y YKVKE 17.83%JAK2 Phospho.ELM 7.0  ViewAnalyzing
11JAK2JAK2_HUMANY1007PQDKE Y YKVKE 17.83%JAK2 HPRD:00993(in vitro;in vivo)  ViewAnalyzing
12JAK2JAK2_HUMANY1007PQDKE Y YKVKE 17.83%ABL1 HPRD:00993(in vitro;in vivo)  ViewAnalyzing
13JAK2JAK2_HUMANY1008QDKEY Y KVKEP 15.47%JAK2 Phospho.ELM 7.0  ViewAnalyzing
14JAK2JAK2_HUMANY1008QDKEY Y KVKEP 15.47%JAK2 HPRD:00993(in vivo)  ViewAnalyzing