Regulatory Network in Protein Phosphorylation
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Substrate: MAP4K1

Description: Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1)(MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)(Hematopoietic progenitor kinase).

Synonyms: HPK1

Ensembl ID: ENSG00000104814

UniprotKB/SwissProt: M4K1_HUMAN (Q92918)

Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MAP4K1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MAP4K1M4K1_HUMANT165AQIGA T LARRL 18.75% Phospho.ELM 7.0View   
2MAP4K1M4K1_HUMANS171LARRL S FIGTP 17.01% Phospho.ELM 7.0View   
3MAP4K1M4K1_HUMANY232MTKSG Y QPPRL 25.57%ABL1 HPRD:03583(in vitro;in vivo)  ViewAnalyzing
4MAP4K1M4K1_HUMANS366PRDLR S SSPRK 42.33% HPRD:03583(in vivo)View   
5MAP4K1M4K1_HUMANS366PRDLR S SSPRK 42.33% Phospho.ELM 7.0View   
6MAP4K1M4K1_HUMANS366PRDLR S SSPRK 42.33% Swiss-Prot 55.0 View   
7MAP4K1M4K1_HUMANS368DLRSS S PRKQL 29.94% Phospho.ELM 7.0View   
8MAP4K1M4K1_HUMANS368DLRSS S PRKQL 29.94% HPRD:03583(in vivo)View   
9MAP4K1M4K1_HUMANS368DLRSS S PRKQL 29.94% Swiss-Prot 55.0 View   
10MAP4K1M4K1_HUMANS374PRKQL S ESSDD 32.70% Phospho.ELM 7.0View   
11MAP4K1M4K1_HUMANS374PRKQL S ESSDD 32.70% Swiss-Prot 55.0 View   
12MAP4K1M4K1_HUMANS376KQLSE S SDDDY 35.37% Phospho.ELM 7.0View   
13MAP4K1M4K1_HUMANS376KQLSE S SDDDY 35.37% Swiss-Prot 55.0 View   
14MAP4K1M4K1_HUMANY381SSDDD Y DDVDI 22.49%Syk Phospho.ELM 7.0  ViewAnalyzing
15MAP4K1M4K1_HUMANY381SSDDD Y DDVDI 22.49% Swiss-Prot 55.0 View   
16MAP4K1M4K1_HUMANY381SSDDD Y DDVDI 22.49%SYK HPRD:03583(in vitro)  ViewAnalyzing
17MAP4K1M4K1_HUMANY381SSDDD Y DDVDI 22.49%LYN HPRD:03583(in vitro)  ViewAnalyzing
18MAP4K1M4K1_HUMANS407KFRSP S DEGPG 49.92% Phospho.ELM 7.0View   
19MAP4K1M4K1_HUMANS407KFRSP S DEGPG 49.92% Swiss-Prot 55.0 View   
20MAP4K1M4K1_HUMANS413DEGPG S MGDDG 23.79% Phospho.ELM 7.0View   
21MAP4K1M4K1_HUMANS413DEGPG S MGDDG 23.79% Swiss-Prot 55.0 View   
22MAP4K1M4K1_HUMANS421DDGQL S PGVLV 16.24% Phospho.ELM 7.0View   
23MAP4K1M4K1_HUMANS421DDGQL S PGVLV 16.24% Swiss-Prot 55.0 View   
24MAP4K1M4K1_HUMANS586PIAHI S PHRLL 12.56% Phospho.ELM 7.0View   
25MAP4K1M4K1_HUMANS586PIAHI S PHRLL 12.56% Swiss-Prot 55.0 View