Regulatory Network in Protein Phosphorylation
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Substrate: MDM2

Description: E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

Ensembl ID: ENSG00000135679

UniprotKB/SwissProt: MDM2_HUMAN (Q00987)

Function: Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 ma
PDB:1RV1
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MDM2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MDM2MDM2_HUMANS157LVSRP S TSSRR 39.55% Phospho.ELM 7.0View   
2MDM2MDM2_HUMANS166RRRAI S ETEEN 37.16%AKT_group Phospho.ELM 7.0 ViewAnalyzing
3MDM2MDM2_HUMANS166RRRAI S ETEEN 37.16%DAPK3 Phospho.ELM 7.0  ViewAnalyzing
4MDM2MDM2_HUMANS172ETEEN S DELSG 35.42%AKT1 HPRD:01272(in vitro;in vivo)  ViewAnalyzing
5MDM2MDM2_HUMANS186RKRHK S DSISL 30.39%AKT_group Phospho.ELM 7.0 ViewAnalyzing
6MDM2MDM2_HUMANS188RHKSD S ISLSF 22.59%AKT_group Phospho.ELM 7.0 ViewAnalyzing
7MDM2MDM2_HUMANS192DSISL S FDESL 24.70%AKT1 HPRD:01272(in vitro;in vivo)  ViewAnalyzing
8MDM2MDM2_HUMANS240WLDQD S VSDQF 20.21% Phospho.ELM 7.0View   
9MDM2MDM2_HUMANS242DQDSV S DQFSV 29.64% Phospho.ELM 7.0View   
10MDM2MDM2_HUMANS246VSDQF S VEFEV 18.33% Phospho.ELM 7.0View   
11MDM2MDM2_HUMANS260DSEDY S LSEEG 37.43% Phospho.ELM 7.0View   
12MDM2MDM2_HUMANS262EDYSL S EEGQE 27.88% Phospho.ELM 7.0View   
13MDM2MDM2_HUMANS269EGQEL S DEDDE 37.90% Phospho.ELM 7.0View   
14MDM2MDM2_HUMANY394QESED Y SQPST 12.73%ABL1 HPRD:01272(in vitro;in vivo)  ViewAnalyzing
15MDM2MDM2_HUMANY394QESED Y SQPST 12.73%ABL1 Phospho.ELM 7.0  ViewAnalyzing
16MDM2MDM2_HUMANS395ESEDY S QPSTS 48.19%ATM Phospho.ELM 7.0  ViewAnalyzing
17MDM2MDM2_HUMANS401QPSTS S SIIYS 26.16%ATM HPRD:01272(in vitro;in vivo)  ViewAnalyzing
18MDM2MDM2_HUMANS407SIIYS S QEDVK 22.18%ATR Phospho.ELM 7.0  ViewAnalyzing