|Description: E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).|
Ensembl ID: ENSG00000135679
UniprotKB/SwissProt: MDM2_HUMAN (Q00987)
Function: Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 ma