Regulatory Network in Protein Phosphorylation
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Substrate: MUC1

Description: Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT)(Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin)(Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut-reactive urinary mucin) (PUM) (Breast carcinoma-associated antigenDF3) (CD227 antigen) [Contains: Mucin-1 alpha subunit (MUC1-alpha)(MUC1-NT); Mucin-1 beta subunit (MUC1-beta) (MUC1-CT)].

Synonyms: PUM

UniprotKB/SwissProt: MUC1_HUMAN (P15941)

Function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, Src and NF- kappaB pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli
PDB:2ACM
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MUC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MUC1MUC1_HUMANT224TSAPD T RPAPG 37.18%PKCd HPRD:01152(in vitro;in vivo)  ViewAnalyzing
2MUC1MUC1_HUMANY1203PARDT Y HPMSE 14.28% Phospho.ELM 7.0View   
3MUC1MUC1_HUMANY1203PARDT Y HPMSE 14.28%PDGFR_group Swiss-Prot 55.0  ViewAnalyzing
4MUC1MUC1_HUMANY1212SEYPT Y HTHGR 10.54% Phospho.ELM 7.0View   
5MUC1MUC1_HUMANY1218HTHGR Y VPPSS 23.15%PDGFR_group Swiss-Prot 55.0  ViewAnalyzing
6MUC1MUC1_HUMANT1224VPPSS T DRSPY 39.51%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
7MUC1MUC1_HUMANT1224VPPSS T DRSPY 39.51%PKCd Swiss-Prot 55.0   ViewAnalyzing
8MUC1MUC1_HUMANT1224VPPSS T DRSPY 39.51%PKCd HPRD:01152(in vitro;in vivo)  ViewAnalyzing
9MUC1MUC1_HUMANS1227SSTDR S PYEKV 34.34%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
10MUC1MUC1_HUMANS1227SSTDR S PYEKV 34.34%GSK3B HPRD:01152(in vitro)  ViewAnalyzing
11MUC1MUC1_HUMANS1227SSTDR S PYEKV 34.34%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
12MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%ZAP70 HPRD:01152(in vitro)  ViewAnalyzing
13MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR HPRD:01152(in vivo)  ViewAnalyzing
14MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR HPRD:01152(in vitro;in vivo)  ViewAnalyzing
15MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR Phospho.ELM 7.0  ViewAnalyzing
16MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%Src Phospho.ELM 7.0  ViewAnalyzing
17MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%SRC Swiss-Prot 55.0   ViewAnalyzing
18MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%EGFR Swiss-Prot 55.0   ViewAnalyzing
19MUC1MUC1_HUMANY1229TDRSP Y EKVSA 29.63%CSK Swiss-Prot 55.0   ViewAnalyzing
20MUC1MUC1_HUMANY1243GSSLS Y TNPAV 18.81% HPRD:01152(in vivo)View   
21MUC1MUC1_HUMANY1243GSSLS Y TNPAV 18.81% HPRD:01152(in vivo)View   
22MUC1MUC1_HUMANY1243GSSLS Y TNPAV 18.81%ABL1 Phospho.ELM 7.0  ViewAnalyzing