Regulatory Network in Protein Phosphorylation
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Substrate: PLSCR1

Description: Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependentphospholipid scramblase 1) (Erythrocyte phospholipid scramblase)(MmTRA1b).

Ensembl ID: ENSG00000188313

UniprotKB/SwissProt: PLS1_HUMAN (O15162)

Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type II membrane protein.
PDB:1Y2A
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PLSCR1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PLSCR1PLS1_HUMANY69PNQPV Y NQPVY 18.11%ABL1 Swiss-Prot 55.0   ViewAnalyzing
2PLSCR1PLS1_HUMANY69PNQPV Y NQPVY 18.11%ABL1 Phospho.ELM 7.0  ViewAnalyzing
3PLSCR1PLS1_HUMANY69PNQPV Y NQPVY 18.11%Src Phospho.ELM 7.0  ViewAnalyzing
4PLSCR1PLS1_HUMANY69PNQPV Y NQPVY 18.11%ABL1 HPRD:08855(in vitro)  ViewAnalyzing
5PLSCR1PLS1_HUMANY74YNQPV Y NQPVG 18.11%ABL1 Phospho.ELM 7.0  ViewAnalyzing
6PLSCR1PLS1_HUMANY74YNQPV Y NQPVG 18.11%ABL1 HPRD:08855(in vitro)  ViewAnalyzing
7PLSCR1PLS1_HUMANY74YNQPV Y NQPVG 18.11%Src Phospho.ELM 7.0  ViewAnalyzing
8PLSCR1PLS1_HUMANY74YNQPV Y NQPVG 18.11%ABL1 Swiss-Prot 55.0   ViewAnalyzing
9PLSCR1PLS1_HUMANT161PSRPF T LRIID 20.15%PKCd HPRD:08855(in vitro;in vivo)  ViewAnalyzing
10PLSCR1PLS1_HUMANT161PSRPF T LRIID 20.15%PKC_group Swiss-Prot 55.0  ViewAnalyzing