Regulatory Network in Protein Phosphorylation
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Substrate: PLSCR4

Description: Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependentphospholipid scramblase 4) (TRA1) (Cell growth-inhibiting gene 43protein).

Ensembl ID: ENSG00000114698

UniprotKB/SwissProt: PLS4_HUMAN (Q9NRQ2)

Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type II membrane protein (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PLSCR4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PLSCR4PLS4_HUMANY83IHPVR Y QPGKY 21.20%ABL Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2PLSCR4PLS4_HUMANY83IHPVR Y QPGKY 21.20%ABL1 Phospho.ELM 7.0  ViewAnalyzing
3PLSCR4PLS4_HUMANY88YQPGK Y PMPNQ 15.64%ABL Swiss-Prot 55.0 (Similarity) ViewAnalyzing
4PLSCR4PLS4_HUMANY88YQPGK Y PMPNQ 15.64%ABL1 Phospho.ELM 7.0  ViewAnalyzing