Regulatory Network in Protein Phosphorylation
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Substrate: PSTPIP1

Description: Proline-serine-threonine phosphatase-interacting protein 1 (PESTphosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

Synonyms: CD2BP1

Ensembl ID: ENSG00000140368

UniprotKB/SwissProt: PPIP1_HUMAN (O43586)

Function: Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2- stimulated adhesion through the coupling of PTPN12 to CD2.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Colocalized with the cortical actin cytoskeleton during interphase, lamellipodia and a
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PSTPIP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PSTPIP1PPIP1_HUMANY345RNEGV Y TAIAV 11.00%ABL1 Phospho.ELM 7.0  ViewAnalyzing
2PSTPIP1PPIP1_HUMANY345RNEGV Y TAIAV 11.00%ABL1 HPRD:05891(in vivo)  ViewAnalyzing