Regulatory Network in Protein Phosphorylation
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Substrate: PTPN6

Description: Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1).

Synonyms: HCP, PTP1C

Ensembl ID: ENSG00000111679

UniprotKB/SwissProt: PTN6_HUMAN (P29350)

Function: Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).
PDB:1FPR
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PTPN6

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PTPN6PTN6_HUMANY377RAYGP Y SVTNC 16.06% Swiss-Prot 55.0 (Similarity)View   
2PTPN6PTN6_HUMANY509QYKFI Y VAIAQ 6.22% Swiss-Prot 55.0 View   
3PTPN6PTN6_HUMANY536GQESE Y GNITY 25.42%ABL1 HPRD:01475(in vitro;in vivo)  ViewAnalyzing
4PTPN6PTN6_HUMANY536GQESE Y GNITY 25.42%INSR HPRD:01475(in vitro;in vivo)  ViewAnalyzing
5PTPN6PTN6_HUMANY536GQESE Y GNITY 25.42%Src Phospho.ELM 7.0  ViewAnalyzing
6PTPN6PTN6_HUMANY536GQESE Y GNITY 25.42%Lck Phospho.ELM 7.0  ViewAnalyzing
7PTPN6PTN6_HUMANY536GQESE Y GNITY 25.42%LCK HPRD:01475(in vitro)  ViewAnalyzing
8PTPN6PTN6_HUMANY536GQESE Y GNITY 25.42%LCK HPRD:01475(in vitro;in vivo)  ViewAnalyzing
9PTPN6PTN6_HUMANY536GQESE Y GNITY 25.42% Swiss-Prot 55.0 (Similarity)View   
10PTPN6PTN6_HUMANY564HKEDV Y ENLHT 16.06%Lck Phospho.ELM 7.0  ViewAnalyzing
11PTPN6PTN6_HUMANY564HKEDV Y ENLHT 16.06%LCK HPRD:01475(in vitro;in vivo)  ViewAnalyzing
12PTPN6PTN6_HUMANY564HKEDV Y ENLHT 16.06%Src Phospho.ELM 7.0  ViewAnalyzing
13PTPN6PTN6_HUMANY564HKEDV Y ENLHT 16.06%LYN HPRD:01475(in vitro;in vivo)  ViewAnalyzing
14PTPN6PTN6_HUMANY564HKEDV Y ENLHT 16.06%ABL1 HPRD:01475(in vitro;in vivo)  ViewAnalyzing
15PTPN6PTN6_HUMANS591EKSKG S LKRK 34.16%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
16PTPN6PTN6_HUMANS591EKSKG S LKRK 34.16%PKCa HPRD:01475(in vitro)  ViewAnalyzing