|Description: Tyrosine-protein phosphatase non-receptor type 6 (EC 220.127.116.11)(Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cellprotein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphataseSHP-1).|
Synonyms: HCP, PTP1C
Ensembl ID: ENSG00000111679
UniprotKB/SwissProt: PTN6_HUMAN (P29350)
Function: Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).