Regulatory Network in Protein Phosphorylation
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Substrate: RAD9A

Description: Cell cycle checkpoint control protein RAD9A (EC (DNA repairexonuclease rad9 homolog A) (hRAD9).

Ensembl ID: ENSG00000172613

UniprotKB/SwissProt: RAD9A_HUMAN (Q99638)

Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RAD9A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RAD9ARAD9A_HUMANY28IGDEL Y LEPLE 13.63%ABL1 Phospho.ELM 7.0  ViewAnalyzing
2RAD9ARAD9A_HUMANY28IGDEL Y LEPLE 13.63%ABL1 HPRD:04788(in vitro;in vivo)  ViewAnalyzing
3RAD9ARAD9A_HUMANY28IGDEL Y LEPLE 13.63% Swiss-Prot 55.0 View   
4RAD9ARAD9A_HUMANS272DTDSH S QDLGS 29.37%ATM HPRD:04788(in vitro;in vivo)  ViewAnalyzing
5RAD9ARAD9A_HUMANS272DTDSH S QDLGS 29.37%ATM Phospho.ELM 7.0  ViewAnalyzing
6RAD9ARAD9A_HUMANS272DTDSH S QDLGS 29.37% Swiss-Prot 55.0 View   
7RAD9ARAD9A_HUMANS277SQDLG S PERHQ 30.77% HPRD:04788(in vitro)View   
8RAD9ARAD9A_HUMANS277SQDLG S PERHQ 30.77% Swiss-Prot 55.0 View   
9RAD9ARAD9A_HUMANS277SQDLG S PERHQ 30.77% Phospho.ELM 7.0View   
10RAD9ARAD9A_HUMANT292LQAHS T PHPDD 18.75% HPRD:04788(in vitro)View   
11RAD9ARAD9A_HUMANS328PSISL S PGPQP 22.48% HPRD:04788(in vitro)View   
12RAD9ARAD9A_HUMANS328PSISL S PGPQP 22.48% Phospho.ELM 7.0View   
13RAD9ARAD9A_HUMANS328PSISL S PGPQP 22.48% Swiss-Prot 55.0 View   
14RAD9ARAD9A_HUMANS336PQPPK S PGPHS 40.64% Phospho.ELM 7.0View   
15RAD9ARAD9A_HUMANS336PQPPK S PGPHS 40.64% HPRD:04788(in vitro)View   
16RAD9ARAD9A_HUMANS341SPGPH S EEEDE 50.24% HPRD:04788(in vitro)View   
17RAD9ARAD9A_HUMANS341SPGPH S EEEDE 50.24% Swiss-Prot 55.0 View   
18RAD9ARAD9A_HUMANS341SPGPH S EEEDE 50.24% Phospho.ELM 7.0View   
19RAD9ARAD9A_HUMANT355STVPG T PPPKK 26.93% Phospho.ELM 7.0View   
20RAD9ARAD9A_HUMANT355STVPG T PPPKK 26.93% HPRD:04788(in vitro)View   
21RAD9ARAD9A_HUMANS375LAPVR S PQGPS 23.08% Phospho.ELM 7.0View   
22RAD9ARAD9A_HUMANS375LAPVR S PQGPS 23.08% HPRD:04788(in vitro)View   
23RAD9ARAD9A_HUMANS375LAPVR S PQGPS 23.08% Swiss-Prot 55.0 View   
24RAD9ARAD9A_HUMANS380SPQGP S PVLAE 34.17% HPRD:04788(in vitro)View   
25RAD9ARAD9A_HUMANS380SPQGP S PVLAE 34.17% Phospho.ELM 7.0View   
26RAD9ARAD9A_HUMANS380SPQGP S PVLAE 34.17% Swiss-Prot 55.0 View   
27RAD9ARAD9A_HUMANS387VLAED S EGEG 38.72% HPRD:04788(in vitro)View   
28RAD9ARAD9A_HUMANS387VLAED S EGEG 38.72% Phospho.ELM 7.0View   
29RAD9ARAD9A_HUMANS387VLAED S EGEG 38.72% Swiss-Prot 55.0 View