Regulatory Network in Protein Phosphorylation
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Substrate: ROBO1

Description: Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twentytwenty).

Synonyms: DUTT1

Ensembl ID: ENSG00000169855

UniprotKB/SwissProt: ROBO1_HUMAN (Q9Y6N7)

Function: Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein (Potential).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ROBO1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ROBO1ROBO1_HUMANS940IRKVP S FTFTP 39.65% Swiss-Prot 55.0 View   
2ROBO1ROBO1_HUMANS940IRKVP S FTFTP 39.65% Phospho.ELM 7.0View   
3ROBO1ROBO1_HUMANY1038PESTV Y GDVDL 14.01%ABL1 Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
4ROBO1ROBO1_HUMANY1073GQPTP Y ATTQL 21.04%ABL1 Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
5ROBO1ROBO1_HUMANY1114VAPVQ Y NIVEQ 13.69%ABL1 Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
6ROBO1ROBO1_HUMANT1240DERGP T PPVRG 42.94% Swiss-Prot 55.0 View   
7ROBO1ROBO1_HUMANT1240DERGP T PPVRG 42.94% Phospho.ELM 7.0View