|Description: Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twentytwenty).|
Ensembl ID: ENSG00000169855
UniprotKB/SwissProt: ROBO1_HUMAN (Q9Y6N7)
Function: Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass type I membrane protein (Potential).