Regulatory Network in Protein Phosphorylation
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Substrate: TOP1

Description: DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

Ensembl ID: ENSG00000198900

UniprotKB/SwissProt: TOP1_HUMAN (P11387)

Function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1A31
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TOP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TOP1TOP1_HUMANS10HLHND S QIEAD 38.07% Phospho.ELM 7.0View   
2TOP1TOP1_HUMANY268MLDHE Y TTKEI 19.11%ABL1 Phospho.ELM 7.0  ViewAnalyzing