Regulatory Network in Protein Phosphorylation
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Substrate: WASL

Description: Neural Wiskott-Aldrich syndrome protein (N-WASP).

Ensembl ID: ENSG00000106299

UniprotKB/SwissProt: WASL_HUMAN (O00401)

Function: Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity).
PDB:2FF3
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of WASL

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1WASLWASL_HUMANY175TTNRF Y GPQVN 25.34%ABL1 HPRD:05448(in vitro;in vivo)  ViewAnalyzing
2WASLWASL_HUMANY256TSKVI Y DFIEK 14.05% Swiss-Prot 55.0 (Similarity)View   
3WASLWASL_HUMANY256TSKVI Y DFIEK 14.05%ABL1 HPRD:05448(in vitro;in vivo)  ViewAnalyzing