|Description: Activated CDC42 kinase 1 (EC 126.96.36.199) (ACK-1) (Tyrosine kinase non-receptor protein 2).|
Ensembl ID: ENSG00000061938
UniprotKB/SwissProt: ACK1_HUMAN (Q07912)
Function: Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane (By similarity).