Regulatory Network in Protein Phosphorylation
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Substrate: TNK2

Description: Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non-receptor protein 2).

Synonyms: ACK1

Ensembl ID: ENSG00000061938

UniprotKB/SwissProt: ACK1_HUMAN (Q07912)

Function: Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane (By similarity).
PDB:1CF4
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TNK2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TNK2ACK1_HUMANS149EWDAP S GKTVS 55.43% Swiss-Prot 55.0 View   
2TNK2ACK1_HUMANS212LAPLG S LLDRL 33.18% Phospho.ELM 7.0View   
3TNK2ACK1_HUMANY284QNDDH Y VMQEH 12.47%ACK(TNK2) Phospho.ELM 7.0 ViewAnalyzing
4TNK2ACK1_HUMANY284QNDDH Y VMQEH 12.47%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
5TNK2ACK1_HUMANY284QNDDH Y VMQEH 12.47%FYN HPRD:06104(in vitro)  ViewAnalyzing
6TNK2ACK1_HUMANY284QNDDH Y VMQEH 12.47% HPRD:06104(in vitro)View   
7TNK2ACK1_HUMANY518VKKPT Y DPVSE 27.12% Phospho.ELM 7.0View   
8TNK2ACK1_HUMANY518VKKPT Y DPVSE 27.12% Swiss-Prot 55.0 View   
9TNK2ACK1_HUMANY826ASDPK Y ATPQV 22.54% Swiss-Prot 55.0 View   
10TNK2ACK1_HUMANY826ASDPK Y ATPQV 22.54% Phospho.ELM 7.0View   
11TNK2ACK1_HUMANY826ASDPK Y ATPQV 22.54% HPRD:06104(in vivo)View   
12TNK2ACK1_HUMANY857VSSTH Y YLLPE 8.90% Phospho.ELM 7.0View   
13TNK2ACK1_HUMANY857VSSTH Y YLLPE 8.90% Swiss-Prot 55.0 View   
14TNK2ACK1_HUMANY858SSTHY Y LLPER 8.31% Phospho.ELM 7.0View   
15TNK2ACK1_HUMANY858SSTHY Y LLPER 8.31% Swiss-Prot 55.0 View   
16TNK2ACK1_HUMANY905PAAPT A TVRPM 11.75% Phospho.ELM 7.0View