Regulatory Network in Protein Phosphorylation
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Substrate: CRK

Description: Proto-oncogene C-crk (p38) (Adapter molecule crk).

Ensembl ID: ENSG00000167193

UniprotKB/SwissProt: CRK_HUMAN (P46108)

Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated to the plasma membrane upon cell adhesion (By similarity).
PDB:1JU5
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CRK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CRKCRK_HUMANS41LVRDS S TSPGD 36.87% Swiss-Prot 55.0 (Similarity)View   
2CRKCRK_HUMANS41LVRDS S TSPGD 36.87% HPRD:01267(in vitro)View   
3CRKCRK_HUMANT42VRDSS T SPGDY 42.78% Swiss-Prot 55.0 (Similarity)View   
4CRKCRK_HUMANY221PEPGP Y AQPSV 24.63%ABL1 Phospho.ELM 7.0  ViewAnalyzing
5CRKCRK_HUMANY221PEPGP Y AQPSV 24.63%ABL1 HPRD:01267(in vitro;in vivo)  ViewAnalyzing
6CRKCRK_HUMANY221PEPGP Y AQPSV 24.63%IGF1R HPRD:01267(in vitro;in vivo)  ViewAnalyzing
7CRKCRK_HUMANY221PEPGP Y AQPSV 24.63%IGF1R Phospho.ELM 7.0  ViewAnalyzing
8CRKCRK_HUMANY221PEPGP Y AQPSV 24.63%EGFR HPRD:01267(in vitro;in vivo)  ViewAnalyzing
9CRKCRK_HUMANY221PEPGP Y AQPSV 24.63%EGFR Phospho.ELM 7.0  ViewAnalyzing
10CRKCRK_HUMANY221PEPGP Y AQPSV 24.63% Swiss-Prot 55.0 View   
11CRKCRK_HUMANY221PEPGP Y AQPSV 24.63%ABL2 HPRD:01267(in vivo)  ViewAnalyzing
12CRKCRK_HUMANY239QNGPI Y ARVIQ 7.47% Swiss-Prot 55.0 View