Regulatory Network in Protein Phosphorylation
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Substrate: CTNND1

Description: Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Srcsubstrate) (CAS) (p120(cas)).

Synonyms: KIAA0384

Ensembl ID: ENSG00000198561

UniprotKB/SwissProt: CTND1_HUMAN (O60716)

Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand- induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Cell membrane (By similarity). Note=Interaction with GLIS2 promotes nuclear translocation (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CTNND1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CTNND1CTND1_HUMANS47ERVRV S PQDAN 13.28% Swiss-Prot 55.0 View   
2CTNND1CTND1_HUMANS47ERVRV S PQDAN 13.28% Phospho.ELM 7.0View   
3CTNND1CTND1_HUMANY96HSHLL Y STIPR 15.32% Swiss-Prot 55.0 View   
4CTNND1CTND1_HUMANY96HSHLL Y STIPR 15.32%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
5CTNND1CTND1_HUMANY112QIVET Y TEEDP 9.92%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
6CTNND1CTND1_HUMANS122PEGAM S VVSVE 20.87% HPRD:03026(in vivo)View   
7CTNND1CTND1_HUMANY174SVSNN Y IQTLG 9.92% Swiss-Prot 55.0 View   
8CTNND1CTND1_HUMANY174SVSNN Y IQTLG 9.92% HPRD:03026(in vivo)View   
9CTNND1CTND1_HUMANY217GYSRH Y EDGYP 18.01% HPRD:03026(in vivo)View   
10CTNND1CTND1_HUMANY217GYSRH Y EDGYP 18.01% Swiss-Prot 55.0 View   
11CTNND1CTND1_HUMANY228GGSDN Y GSLSR 17.06% Swiss-Prot 55.0 View   
12CTNND1CTND1_HUMANY228GGSDN Y GSLSR 17.06%EGFR HPRD:03026(in vitro;in vivo)  ViewAnalyzing
13CTNND1CTND1_HUMANY228GGSDN Y GSLSR 17.06%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
14CTNND1CTND1_HUMANS252GYRAP S RQDVY 41.40%GSK3B HPRD:03026(in vitro;in vivo)  ViewAnalyzing
15CTNND1CTND1_HUMANY257SRQDV Y GPQPQ 31.23%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
16CTNND1CTND1_HUMANY257SRQDV Y GPQPQ 31.23% Swiss-Prot 55.0 View   
17CTNND1CTND1_HUMANS268VRVGG S SVDLH 22.66% Swiss-Prot 55.0 View   
18CTNND1CTND1_HUMANS268VRVGG S SVDLH 22.66% Phospho.ELM 7.0View   
19CTNND1CTND1_HUMANS268VRVGG S SVDLH 22.66% HPRD:03026(in vivo)View   
20CTNND1CTND1_HUMANS269RVGGS S VDLHR 23.95% Phospho.ELM 7.0View   
21CTNND1CTND1_HUMANS269RVGGS S VDLHR 23.95% Swiss-Prot 55.0 View   
22CTNND1CTND1_HUMANY280FHPEP Y GLEDD 32.45%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
23CTNND1CTND1_HUMANY280FHPEP Y GLEDD 32.45% Swiss-Prot 55.0 View   
24CTNND1CTND1_HUMANS288EDDQR S MGYDD 15.78% HPRD:03026(in vivo)View   
25CTNND1CTND1_HUMANS288EDDQR S MGYDD 15.78% Swiss-Prot 55.0 (Similarity)View   
26CTNND1CTND1_HUMANY291QRSMG Y DDLDY 9.53%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
27CTNND1CTND1_HUMANY291QRSMG Y DDLDY 9.53% Swiss-Prot 55.0 (Similarity)View   
28CTNND1CTND1_HUMANY296YDDLD Y GMMSD 17.76%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
29CTNND1CTND1_HUMANY302GMMSD Y GTARR 14.74%SRC HPRD:03026(in vitro;in vivo)  ViewAnalyzing
30CTNND1CTND1_HUMANY302GMMSD Y GTARR 14.74% Swiss-Prot 55.0 View   
31CTNND1CTND1_HUMANT310ARRTG T PSDPR 21.00%GSK3B HPRD:03026(in vitro;in vivo)  ViewAnalyzing
32CTNND1CTND1_HUMANT310ARRTG T PSDPR 21.00% Phospho.ELM 7.0View   
33CTNND1CTND1_HUMANT310ARRTG T PSDPR 21.00% Swiss-Prot 55.0 View   
34CTNND1CTND1_HUMANS312RTGTP S DPRRR 61.15% HPRD:03026(in vivo)View   
35CTNND1CTND1_HUMANS320RRRLR S YEDMI 37.15% Swiss-Prot 55.0 (Similarity)View   
36CTNND1CTND1_HUMANY321RRLRS Y EDMIG 14.98% HPRD:03026(in vivo)View   
37CTNND1CTND1_HUMANY321RRLRS Y EDMIG 14.98% Swiss-Prot 55.0 View   
38CTNND1CTND1_HUMANY334VPSDQ Y YWAPL 13.13% Swiss-Prot 55.0 View   
39CTNND1CTND1_HUMANY334VPSDQ Y YWAPL 13.13% HPRD:03026(in vivo)View   
40CTNND1CTND1_HUMANS349RGSLA S LDSLR 37.69% Swiss-Prot 55.0 View   
41CTNND1CTND1_HUMANS349RGSLA S LDSLR 37.69% Phospho.ELM 7.0View   
42CTNND1CTND1_HUMANS349RGSLA S LDSLR 37.69% Phospho.ELM 7.0View   
43CTNND1CTND1_HUMANS349RGSLA S LDSLR 37.69% HPRD:03026(in vivo)View   
44CTNND1CTND1_HUMANS352LASLD S LRKGG 35.05% Phospho.ELM 7.0View   
45CTNND1CTND1_HUMANS352LASLD S LRKGG 35.05% Swiss-Prot 55.0 View   
46CTNND1CTND1_HUMANS352LASLD S LRKGG 35.05% HPRD:03026(in vivo)View   
47CTNND1CTND1_HUMANS859NNASR S QSSHS 31.73% Swiss-Prot 55.0 (Similarity)View   
48CTNND1CTND1_HUMANY865QSSHS Y DDSTL 20.53% HPRD:03026(in vivo)View   
49CTNND1CTND1_HUMANY865QSSHS Y DDSTL 20.53% Swiss-Prot 55.0 View   
50CTNND1CTND1_HUMANS879DRNQK S DKKPD 44.92% Phospho.ELM 7.0View   
51CTNND1CTND1_HUMANY904SLDNN Y STPNE 21.85% Swiss-Prot 55.0 (Similarity)View   
52CTNND1CTND1_HUMANT916GDHNR T LDRSG 38.02% Swiss-Prot 55.0 View   
53CTNND1CTND1_HUMANT916GDHNR T LDRSG 38.02% Phospho.ELM 7.0View   
54CTNND1CTND1_HUMANT916GDHNR T LDRSG 38.02% HPRD:03026(in vivo)View   
55CTNND1CTND1_HUMANS920RTLDR S GDLGD 36.00% Phospho.ELM 7.0View