Regulatory Network in Protein Phosphorylation
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Substrate: EGFR

Description: Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptortyrosine-protein kinase ErbB-1).

Synonyms: ERBB1

Ensembl ID: ENSG00000146648

UniprotKB/SwissProt: EGFR_HUMAN (P00533)

Function: Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. Isoform 2/truncated isoform may act as an antagonist.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
PDB:1DNQ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EGFR

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EGFREGFR_HUMANT678IVRKR T LRRLL 27.87%PKC_group Swiss-Prot 55.0  ViewAnalyzing
2EGFREGFR_HUMANT678IVRKR T LRRLL 27.87%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
3EGFREGFR_HUMANT678IVRKR T LRRLL 27.87%PKCd HPRD:00579(in vivo)  ViewAnalyzing
4EGFREGFR_HUMANT678IVRKR T LRRLL 27.87%PKC_group Phospho.ELM 7.0 ViewAnalyzing
5EGFREGFR_HUMANT693LVEPL T PSGEA 26.56%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
6EGFREGFR_HUMANT693LVEPL T PSGEA 26.56% Swiss-Prot 55.0 View   
7EGFREGFR_HUMANT693LVEPL T PSGEA 26.56% HPRD:00579(in vivo)View   
8EGFREGFR_HUMANT693LVEPL T PSGEA 26.56%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
9EGFREGFR_HUMANS695EPLTP S GEAPN 43.99% HPRD:00579(in vitro)View   
10EGFREGFR_HUMANS695EPLTP S GEAPN 43.99% Phospho.ELM 7.0View   
11EGFREGFR_HUMANS695EPLTP S GEAPN 43.99% Swiss-Prot 55.0 View   
12EGFREGFR_HUMANS768AYVMA S VDNPH 16.35%CaMK2a HPRD:00579(in vitro)  ViewAnalyzing
13EGFREGFR_HUMANS768AYVMA S VDNPH 16.35%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
14EGFREGFR_HUMANY869AEEKE Y HAEGG 19.87%SRC HPRD:00579(in vitro)  ViewAnalyzing
15EGFREGFR_HUMANY869AEEKE Y HAEGG 19.87%Src Phospho.ELM 7.0  ViewAnalyzing
16EGFREGFR_HUMANY915FGSKP Y DGIPA 30.45%SRC HPRD:00579(in vitro)  ViewAnalyzing
17EGFREGFR_HUMANY915FGSKP Y DGIPA 30.45%Src Phospho.ELM 7.0  ViewAnalyzing
18EGFREGFR_HUMANY944CTIDV Y MIMVK 4.16%SRC HPRD:00579(in vitro)  ViewAnalyzing
19EGFREGFR_HUMANY944CTIDV Y MIMVK 4.16%Src Phospho.ELM 7.0  ViewAnalyzing
20EGFREGFR_HUMANY978RDPQR Y LVIQG 10.48% Phospho.ELM 7.0View   
21EGFREGFR_HUMANY978RDPQR Y LVIQG 10.48% Swiss-Prot 55.0 View   
22EGFREGFR_HUMANS991RMHLP S PTDSN 46.95% HPRD:00579(in vivo)View   
23EGFREGFR_HUMANS991RMHLP S PTDSN 46.95% Swiss-Prot 55.0 View   
24EGFREGFR_HUMANS991RMHLP S PTDSN 46.95% Phospho.ELM 7.0View   
25EGFREGFR_HUMANS995PSPTD S NFYRA 31.17% Swiss-Prot 55.0 View   
26EGFREGFR_HUMANY998TDSNF Y RALMD 10.14% HPRD:00579(in vivo)View   
27EGFREGFR_HUMANY998TDSNF Y RALMD 10.14% Phospho.ELM 7.0View   
28EGFREGFR_HUMANY998TDSNF Y RALMD 10.14% Swiss-Prot 55.0 View   
29EGFREGFR_HUMANY1016VDADE Y LIPQQ 15.52%EGFR Phospho.ELM 7.0  ViewAnalyzing
30EGFREGFR_HUMANY1016VDADE Y LIPQQ 15.52%EGFR HPRD:00579(in vitro)  ViewAnalyzing
31EGFREGFR_HUMANS1026QGFFS S PSTSR 20.08% Swiss-Prot 55.0 View   
32EGFREGFR_HUMANS1026QGFFS S PSTSR 20.08% HPRD:00579(in vivo)View   
33EGFREGFR_HUMANS1026QGFFS S PSTSR 20.08%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
34EGFREGFR_HUMANS1028FFSSP S TSRTP 40.75% Phospho.ELM 7.0View   
35EGFREGFR_HUMANS1039LLSSL S ATSNN 31.30% Phospho.ELM 7.0View   
36EGFREGFR_HUMANS1042SLSAT S NNSTV 33.46% Phospho.ELM 7.0View   
37EGFREGFR_HUMANS1045ATSNN S TVACI 28.63% Phospho.ELM 7.0View   
38EGFREGFR_HUMANS1064PIKED S FLQRY 29.02%CaMK2a HPRD:00579(in vitro)  ViewAnalyzing
39EGFREGFR_HUMANS1064PIKED S FLQRY 29.02% Swiss-Prot 55.0 View   
40EGFREGFR_HUMANS1064PIKED S FLQRY 29.02% Phospho.ELM 7.0View   
41EGFREGFR_HUMANY1069SFLQR Y SSDPT 10.28%JAK2 HPRD:00579(in vitro;in vivo)  ViewAnalyzing
42EGFREGFR_HUMANY1069SFLQR Y SSDPT 10.28%EGFR HPRD:00579(in vivo)  ViewAnalyzing
43EGFREGFR_HUMANY1069SFLQR Y SSDPT 10.28% Swiss-Prot 55.0 View   
44EGFREGFR_HUMANY1069SFLQR Y SSDPT 10.28% Phospho.ELM 7.0View   
45EGFREGFR_HUMANS1070FLQRY S SDPTG 30.38%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
46EGFREGFR_HUMANS1070FLQRY S SDPTG 30.38%CaMK2g HPRD:00579(in vitro)  ViewAnalyzing
47EGFREGFR_HUMANS1070FLQRY S SDPTG 30.38% Swiss-Prot 55.0 View   
48EGFREGFR_HUMANS1070FLQRY S SDPTG 30.38%CaMK2a HPRD:00579(in vitro)  ViewAnalyzing
49EGFREGFR_HUMANS1071LQRYS S DPTGA 38.38%CaMK2a HPRD:00579(in vitro)  ViewAnalyzing
50EGFREGFR_HUMANS1071LQRYS S DPTGA 38.38% Swiss-Prot 55.0 View   
51EGFREGFR_HUMANS1071LQRYS S DPTGA 38.38%CaMK2g HPRD:00579(in vitro)  ViewAnalyzing
52EGFREGFR_HUMANS1071LQRYS S DPTGA 38.38%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
53EGFREGFR_HUMANS1081ALTED S IDDTF 22.99%CaMK2a HPRD:00579(in vitro)  ViewAnalyzing
54EGFREGFR_HUMANS1081ALTED S IDDTF 22.99%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
55EGFREGFR_HUMANY1092LPVPE Y INQSV 10.09%EGFR Phospho.ELM 7.0  ViewAnalyzing
56EGFREGFR_HUMANY1092LPVPE Y INQSV 10.09%EGFR HPRD:00579(in vitro)  ViewAnalyzing
57EGFREGFR_HUMANY1092LPVPE Y INQSV 10.09%SRC HPRD:00579(in vitro)  ViewAnalyzing
58EGFREGFR_HUMANY1092LPVPE Y INQSV 10.09%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
59EGFREGFR_HUMANS1104KRPAG S VQNPV 23.72% Phospho.ELM 7.0View   
60EGFREGFR_HUMANY1110VQNPV Y HNQPL 9.05%EGFR Phospho.ELM 7.0  ViewAnalyzing
61EGFREGFR_HUMANY1110VQNPV Y HNQPL 9.05%EGFR HPRD:00579(in vitro)  ViewAnalyzing
62EGFREGFR_HUMANY1110VQNPV Y HNQPL 9.05%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
63EGFREGFR_HUMANS1120LNPAP S RDPHY 51.96%CaMK2a HPRD:00579(in vitro)  ViewAnalyzing
64EGFREGFR_HUMANY1125SRDPH Y QDPHS 21.72%SRC HPRD:00579(in vitro)  ViewAnalyzing
65EGFREGFR_HUMANY1125SRDPH Y QDPHS 21.72%Src Phospho.ELM 7.0  ViewAnalyzing
66EGFREGFR_HUMANY1138VGNPE Y LNTVQ 13.40% Swiss-Prot 55.0 View   
67EGFREGFR_HUMANY1138VGNPE Y LNTVQ 13.40% HPRD:00579(in vitro)View   
68EGFREGFR_HUMANS1166GSHQI S LDNPD 24.09%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
69EGFREGFR_HUMANS1166GSHQI S LDNPD 24.09%CaMK2a HPRD:00579(in vitro)  ViewAnalyzing
70EGFREGFR_HUMANS1166GSHQI S LDNPD 24.09% Swiss-Prot 55.0 View   
71EGFREGFR_HUMANY1172LDNPD Y QQDFF 14.88%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
72EGFREGFR_HUMANY1172LDNPD Y QQDFF 14.88%EGFR HPRD:00579(in vitro)  ViewAnalyzing
73EGFREGFR_HUMANY1172LDNPD Y QQDFF 14.88%EGFR Phospho.ELM 7.0  ViewAnalyzing
74EGFREGFR_HUMANS1190GIFKG S TAENA 25.65% Phospho.ELM 7.0View   
75EGFREGFR_HUMANY1197AENAE Y LRVAP 9.44%EGFR Phospho.ELM 7.0  ViewAnalyzing
76EGFREGFR_HUMANY1197AENAE Y LRVAP 9.44%EGFR HPRD:00579(in vitro)  ViewAnalyzing
77EGFREGFR_HUMANY1197AENAE Y LRVAP 9.44%autocatalysis Swiss-Prot 55.0  ViewAnalyzing