Regulatory Network in Protein Phosphorylation
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Substrate: ERBB2

Description: Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1)(p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cellsurface receptor HER2) (MLN 19) (CD340 antigen).

Synonyms: HER2, NEU, NGL

Ensembl ID: ENSG00000141736

UniprotKB/SwissProt: ERBB2_HUMAN (P04626)

Function: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1N8Z
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ERBB2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ERBB2ERBB2_HUMANT686KIRKY T MRRLL 13.77% Phospho.ELM 7.0View   
2ERBB2ERBB2_HUMANY877IDETE Y HADGG 15.10% HPRD:01281(in vitro)View   
3ERBB2ERBB2_HUMANY877IDETE Y HADGG 15.10% Phospho.ELM 7.0View   
4ERBB2ERBB2_HUMANY1023VDAEE Y LVPQQ 12.42%ErbB2 HPRD:01281(in vitro)  ViewAnalyzing
5ERBB2ERBB2_HUMANY1112SPLQR Y SEDPT 11.94% Phospho.ELM 7.0View   
6ERBB2ERBB2_HUMANY1139SPQPE Y VNQPD 16.04%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
7ERBB2ERBB2_HUMANY1139SPQPE Y VNQPD 16.04%ErbB2 Phospho.ELM 7.0  ViewAnalyzing
8ERBB2ERBB2_HUMANY1139SPQPE Y VNQPD 16.04%ErbB2 HPRD:01281(in vitro)  ViewAnalyzing
9ERBB2ERBB2_HUMANT1172LERPK T LSPGK 34.84%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
10ERBB2ERBB2_HUMANY1196VENPE Y LTPQG 19.68%ErbB2 Phospho.ELM 7.0  ViewAnalyzing
11ERBB2ERBB2_HUMANY1196VENPE Y LTPQG 19.68% HPRD:01281(in vitro)View   
12ERBB2ERBB2_HUMANY1196VENPE Y LTPQG 19.68% Swiss-Prot 55.0 (Potential)View   
13ERBB2ERBB2_HUMANY1221AFDNL Y YWDQD 14.57%ErbB2 Phospho.ELM 7.0  ViewAnalyzing
14ERBB2ERBB2_HUMANY1221AFDNL Y YWDQD 14.57%ErbB2 HPRD:01281(in vitro)  ViewAnalyzing
15ERBB2ERBB2_HUMANY1222FDNLY Y WDQDP 12.99%ErbB2 HPRD:01281(in vitro)  ViewAnalyzing
16ERBB2ERBB2_HUMANY1222FDNLY Y WDQDP 12.99%ErbB2 Phospho.ELM 7.0  ViewAnalyzing
17ERBB2ERBB2_HUMANY1248AENPE Y LGLDV 13.81%ErbB2 HPRD:01281(in vitro)  ViewAnalyzing
18ERBB2ERBB2_HUMANY1248AENPE Y LGLDV 13.81%ErbB2 Phospho.ELM 7.0  ViewAnalyzing
19ERBB2ERBB2_HUMANY1248AENPE Y LGLDV 13.81% HPRD:01281(in vivo)View   
20ERBB2ERBB2_HUMANY1248AENPE Y LGLDV 13.81%EGFR HPRD:01281(in vivo)  ViewAnalyzing
21ERBB2ERBB2_HUMANY1248AENPE Y LGLDV 13.81%EGFR HPRD:01281(in vitro)  ViewAnalyzing
22ERBB2ERBB2_HUMANY1248AENPE Y LGLDV 13.81%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
23ERBB2ERBB2_HUMANY1248AENPE Y LGLDV 13.81%ErbB2 HPRD:01281(in vivo)  ViewAnalyzing