|Description: Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3adapter GRB2) (Protein Ash).|
Ensembl ID: ENSG00000177885
UniprotKB/SwissProt: GRB2_HUMAN (P62993)
Function: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus (By similarity).