Regulatory Network in Protein Phosphorylation
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Substrate: PLCG1

Description: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1(EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1)(Phospholipase C-gamma-1) (PLC-II) (PLC-148).

Synonyms: PLC1

Ensembl ID: ENSG00000124181

UniprotKB/SwissProt: PLCG1_HUMAN (P19174)

Function: PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1HSQ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PLCG1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PLCG1PLCG1_HUMANY379GMPVI Y HGHTL 11.28% Swiss-Prot 55.0 (Similarity)View   
2PLCG1PLCG1_HUMANY472AEGSA Y EEVPT 17.83%EGFR HPRD:01398(in vitro;in vivo)  ViewAnalyzing
3PLCG1PLCG1_HUMANY472AEGSA Y EEVPT 17.83%EGFR Phospho.ELM 7.0  ViewAnalyzing
4PLCG1PLCG1_HUMANY472AEGSA Y EEVPT 17.83%FGFR1 Phospho.ELM 7.0  ViewAnalyzing
5PLCG1PLCG1_HUMANY481PTSMM Y SENDI 12.28% Swiss-Prot 55.0 (Similarity)View   
6PLCG1PLCG1_HUMANY506VNHEW Y PHYFV 4.16% Swiss-Prot 55.0 (Similarity)View   
7PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%HCK HPRD:01398(in vitro)  ViewAnalyzing
8PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%SYK HPRD:01398(in vitro)  ViewAnalyzing
9PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%FGFR_group Phospho.ELM 7.0 ViewAnalyzing
10PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%PDGFR_group Phospho.ELM 7.0 ViewAnalyzing
11PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%LYN HPRD:01398(in vitro)  ViewAnalyzing
12PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%FGFR1 Phospho.ELM 7.0  ViewAnalyzing
13PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%Sky Phospho.ELM 7.0 ViewAnalyzing
14PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%EGFR Phospho.ELM 7.0  ViewAnalyzing
15PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%EGFR HPRD:01398(in vitro)  ViewAnalyzing
16PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27% Swiss-Prot 55.0 View   
17PLCG1PLCG1_HUMANY771TAEPD Y GALYE 18.27%Syk Phospho.ELM 7.0  ViewAnalyzing
18PLCG1PLCG1_HUMANY775DYGAL Y EGRNP 18.79% HPRD:01398(in vivo)View   
19PLCG1PLCG1_HUMANY775DYGAL Y EGRNP 18.79% Swiss-Prot 55.0 View   
20PLCG1PLCG1_HUMANY775DYGAL Y EGRNP 18.79% Phospho.ELM 7.0View   
21PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%HCK HPRD:01398(in vitro;in vivo)  ViewAnalyzing
22PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86% HPRD:01398(in vivo)View   
23PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86% HPRD:01398(in vitro)View   
24PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%RET HPRD:01398(in vitro)  ViewAnalyzing
25PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%SRC HPRD:01398(in vitro;in vivo)  ViewAnalyzing
26PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%LYN HPRD:01398(in vitro;in vivo)  ViewAnalyzing
27PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%PDGFR_group Phospho.ELM 7.0 ViewAnalyzing
28PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%EGFR HPRD:01398(in vitro;in vivo)  ViewAnalyzing
29PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86% Swiss-Prot 55.0 View   
30PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%SYK HPRD:01398(in vitro;in vivo)  ViewAnalyzing
31PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%Syk Phospho.ELM 7.0  ViewAnalyzing
32PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%FGFR_group Phospho.ELM 7.0 ViewAnalyzing
33PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%FGFR1 Phospho.ELM 7.0  ViewAnalyzing
34PLCG1PLCG1_HUMANY783RNPGF Y VEANP 11.86%EGFR Phospho.ELM 7.0  ViewAnalyzing
35PLCG1PLCG1_HUMANY977TERAC Y RDMSS 14.52% Swiss-Prot 55.0 (Similarity)View   
36PLCG1PLCG1_HUMANS1248RAREG S FESRY 22.53%PKD1 HPRD:01398(in vitro)  ViewAnalyzing
37PLCG1PLCG1_HUMANS1248RAREG S FESRY 22.53%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
38PLCG1PLCG1_HUMANS1248RAREG S FESRY 22.53%PKA_group Phospho.ELM 7.0 ViewAnalyzing
39PLCG1PLCG1_HUMANY1253SFESR Y QQPFE 22.30% HPRD:01398(in vivo)View   
40PLCG1PLCG1_HUMANY1253SFESR Y QQPFE 22.30% Swiss-Prot 55.0 View   
41PLCG1PLCG1_HUMANY1253SFESR Y QQPFE 22.30%PDGFR_group Phospho.ELM 7.0 ViewAnalyzing
42PLCG1PLCG1_HUMANY1253SFESR Y QQPFE 22.30%FGFR_group Phospho.ELM 7.0 ViewAnalyzing
43PLCG1PLCG1_HUMANY1253SFESR Y QQPFE 22.30%EGFR Phospho.ELM 7.0  ViewAnalyzing
44PLCG1PLCG1_HUMANY1253SFESR Y QQPFE 22.30%HCK HPRD:01398(in vitro;in vivo)  ViewAnalyzing
45PLCG1PLCG1_HUMANY1253SFESR Y QQPFE 22.30%FGFR1 Phospho.ELM 7.0  ViewAnalyzing