|Description: Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).|
Ensembl ID: ENSG00000115145
UniprotKB/SwissProt: STAM2_HUMAN (O75886)
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).