Regulatory Network in Protein Phosphorylation
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Substrate: STAT1

Description: Signal transducer and activator of transcription 1-alpha/beta(Transcription factor ISGF-3 components p91/p84).

Ensembl ID: ENSG00000115415

UniprotKB/SwissProt: STAT1_HUMAN (P42224)

Function: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
PDB:1BF5
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STAT1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%KIT HPRD:02777(in vivo)  ViewAnalyzing
2STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%JAK1 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
3STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%JAK2 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
4STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%LCK HPRD:02777(in vitro;in vivo)  ViewAnalyzing
5STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%LCK HPRD:02777(in vitro;in vivo)  ViewAnalyzing
6STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%Src Phospho.ELM 7.0  ViewAnalyzing
7STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%JAK2 Phospho.ELM 7.0  ViewAnalyzing
8STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%JAK2 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
9STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%TYK2 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
10STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%TYK2 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
11STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09% HPRD:02777(in vivo)View   
12STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%EGFR HPRD:02777(in vitro;in vivo)  ViewAnalyzing
13STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%JAK1 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
14STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%JAK1 Phospho.ELM 7.0  ViewAnalyzing
15STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%EGFR Phospho.ELM 7.0  ViewAnalyzing
16STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%EGFR HPRD:02777(in vitro;in vivo)  ViewAnalyzing
17STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%FGFR3 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
18STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%FGFR3 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
19STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%FGFR4 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
20STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%FGFR4 HPRD:02777(in vitro;in vivo)  ViewAnalyzing
21STAT1STAT1_HUMANY701PKGTG Y IKTEL 10.09%JAK1 Swiss-Prot 55.0   ViewAnalyzing
22STAT1STAT1_HUMANS727NLLPM S PEEFD 27.50% Phospho.ELM 7.0View   
23STAT1STAT1_HUMANS727NLLPM S PEEFD 27.50%PKCd HPRD:02777(in vitro;in vivo)  ViewAnalyzing
24STAT1STAT1_HUMANS727NLLPM S PEEFD 27.50%MSK1 HPRD:02777(in vitro)  ViewAnalyzing
25STAT1STAT1_HUMANS727NLLPM S PEEFD 27.50% HPRD:02777(in vitro)View   
26STAT1STAT1_HUMANS727NLLPM S PEEFD 27.50%CaMK2g HPRD:02777(in vitro)  ViewAnalyzing
27STAT1STAT1_HUMANS727NLLPM S PEEFD 27.50% Swiss-Prot 55.0 View