Regulatory Network in Protein Phosphorylation
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Substrate: ANXA1

Description: Annexin A1 (Annexin-1) (Annexin I) (Lipocortin I) (Calpactin II)(Chromobindin-9) (p35) (Phospholipase A2 inhibitory protein).

Synonyms: ANX1, LPC1

Ensembl ID: ENSG00000135046

UniprotKB/SwissProt: ANXA1_HUMAN (P04083)

Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By simi
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ANXA1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ANXA1ANXA1_HUMANS5-MAMV S EFLKQ 15.00%ChaK1(TRPM7) Swiss-Prot 55.0  ViewAnalyzing
2ANXA1ANXA1_HUMANS5-MAMV S EFLKQ 15.00% Phospho.ELM 7.0View   
3ANXA1ANXA1_HUMANS5-MAMV S EFLKQ 15.00%ChaK1 HPRD:01060(in vitro;in vivo)  ViewAnalyzing
4ANXA1ANXA1_HUMANY21NEEQE Y VQTVK 9.50%SRC HPRD:01060(in vitro)  ViewAnalyzing
5ANXA1ANXA1_HUMANY21NEEQE Y VQTVK 9.50%Src Phospho.ELM 7.0  ViewAnalyzing
6ANXA1ANXA1_HUMANY21NEEQE Y VQTVK 9.50%EGFR Phospho.ELM 7.0  ViewAnalyzing