Regulatory Network in Protein Phosphorylation
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Substrate: CBL

Description: E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transductionprotein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55).

Synonyms: CBL2, RNF55

Ensembl ID: ENSG00000110395

UniprotKB/SwissProt: CBL_HUMAN (P22681)

Function: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:1B47
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CBL

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CBLCBL_HUMANY337FREGF Y LFPDG 20.49% Phospho.ELM 7.0View   
2CBLCBL_HUMANY368VTQEQ Y ELYCE 13.72% Phospho.ELM 7.0View   
3CBLCBL_HUMANY371EQYEL Y CEMGS 3.71%EGFR Phospho.ELM 7.0  ViewAnalyzing
4CBLCBL_HUMANY371EQYEL Y CEMGS 3.71%InsR Phospho.ELM 7.0  ViewAnalyzing
5CBLCBL_HUMANY371EQYEL Y CEMGS 3.71%INSR HPRD:01320(in vitro)  ViewAnalyzing
6CBLCBL_HUMANY371EQYEL Y CEMGS 3.71%INSR Swiss-Prot 55.0   ViewAnalyzing
7CBLCBL_HUMANY552PPDRP Y SVGAE 19.51% Swiss-Prot 55.0 View   
8CBLCBL_HUMANY552PPDRP Y SVGAE 19.51% Phospho.ELM 7.0View   
9CBLCBL_HUMANS619LTNRH S LPFSL 34.20%PKCa HPRD:01320(in vitro)  ViewAnalyzing
10CBLCBL_HUMANS623HSLPF S LPSQM 37.11%PKCa HPRD:01320(in vitro)  ViewAnalyzing
11CBLCBL_HUMANS639VPRLG S TFSLD 30.76%PKCa HPRD:01320(in vitro)  ViewAnalyzing
12CBLCBL_HUMANS642LGSTF S LDTSM 25.98%PKCa HPRD:01320(in vitro)  ViewAnalyzing
13CBLCBL_HUMANS667PKIKP S SSANA 31.74% Swiss-Prot 55.0 View   
14CBLCBL_HUMANS667PKIKP S SSANA 31.74% Phospho.ELM 7.0View   
15CBLCBL_HUMANS667PKIKP S SSANA 31.74% HPRD:01320(in vivo)View   
16CBLCBL_HUMANS668KIKPS S SANAI 41.83% Swiss-Prot 55.0 (Similarity)View   
17CBLCBL_HUMANS669IKPSS S ANAIY 29.85% Swiss-Prot 55.0 View   
18CBLCBL_HUMANS669IKPSS S ANAIY 29.85% Phospho.ELM 7.0View   
19CBLCBL_HUMANS669IKPSS S ANAIY 29.85% HPRD:01320(in vitro)View   
20CBLCBL_HUMANY674SANAI Y SLAAR 8.67% Phospho.ELM 7.0View   
21CBLCBL_HUMANY674SANAI Y SLAAR 8.67% HPRD:01320(in vitro;in vivo)View   
22CBLCBL_HUMANY674SANAI Y SLAAR 8.67% Swiss-Prot 55.0 View   
23CBLCBL_HUMANS675ANAIY S LAARP 12.86% HPRD:01320(in vivo)View   
24CBLCBL_HUMANS675ANAIY S LAARP 12.86% Swiss-Prot 55.0 View   
25CBLCBL_HUMANS675ANAIY S LAARP 12.86% Phospho.ELM 7.0View   
26CBLCBL_HUMANY700EEDTE Y MTPSS 14.37%ABL1 Phospho.ELM 7.0  ViewAnalyzing
27CBLCBL_HUMANY700EEDTE Y MTPSS 14.37%Fyn Phospho.ELM 7.0  ViewAnalyzing
28CBLCBL_HUMANY700EEDTE Y MTPSS 14.37%InsR Phospho.ELM 7.0  ViewAnalyzing
29CBLCBL_HUMANY700EEDTE Y MTPSS 14.37%Yes Phospho.ELM 7.0  ViewAnalyzing
30CBLCBL_HUMANY700EEDTE Y MTPSS 14.37%EGFR HPRD:01320(in vivo)  ViewAnalyzing
31CBLCBL_HUMANY700EEDTE Y MTPSS 14.37%Syk Phospho.ELM 7.0  ViewAnalyzing
32CBLCBL_HUMANY700EEDTE Y MTPSS 14.37% Swiss-Prot 55.0 View   
33CBLCBL_HUMANY700EEDTE Y MTPSS 14.37%Lck Phospho.ELM 7.0  ViewAnalyzing
34CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%Syk Phospho.ELM 7.0  ViewAnalyzing
35CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%FYN HPRD:01320(in vivo)  ViewAnalyzing
36CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%Lck Phospho.ELM 7.0  ViewAnalyzing
37CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%HCK HPRD:01320(in vivo)  ViewAnalyzing
38CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%HCK Phospho.ELM 7.0  ViewAnalyzing
39CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%Fyn Phospho.ELM 7.0  ViewAnalyzing
40CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%Yes Phospho.ELM 7.0  ViewAnalyzing
41CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%EGFR HPRD:01320(in vivo)  ViewAnalyzing
42CBLCBL_HUMANY731IDSCT Y EAMYN 13.15%Src Phospho.ELM 7.0  ViewAnalyzing
43CBLCBL_HUMANY774NEDDG Y DVPKP 22.29%ABL1 Phospho.ELM 7.0  ViewAnalyzing
44CBLCBL_HUMANY774NEDDG Y DVPKP 22.29%Src Phospho.ELM 7.0  ViewAnalyzing
45CBLCBL_HUMANY774NEDDG Y DVPKP 22.29%Lck Phospho.ELM 7.0  ViewAnalyzing
46CBLCBL_HUMANY774NEDDG Y DVPKP 22.29% Swiss-Prot 55.0 View   
47CBLCBL_HUMANY774NEDDG Y DVPKP 22.29%InsR Phospho.ELM 7.0  ViewAnalyzing
48CBLCBL_HUMANY774NEDDG Y DVPKP 22.29%Syk Phospho.ELM 7.0  ViewAnalyzing
49CBLCBL_HUMANY774NEDDG Y DVPKP 22.29%EGFR HPRD:01320(in vivo)  ViewAnalyzing
50CBLCBL_HUMANY774NEDDG Y DVPKP 22.29%Fyn Phospho.ELM 7.0  ViewAnalyzing
51CBLCBL_HUMANS900FVSIS S PAHVA 25.16% Swiss-Prot 55.0 View