Regulatory Network in Protein Phosphorylation
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Substrate: EPS15

Description: Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1pprotein).

Synonyms: AF1P

Ensembl ID: ENSG00000085832

UniprotKB/SwissProt: EP15_HUMAN (P42566)

Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits (By similarity).
PDB:1C07
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EPS15

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EPS15EP15_HUMANS323KNIIG S SPVAD 22.51% Swiss-Prot 55.0 View   
2EPS15EP15_HUMANS324NIIGS S PVADF 20.41% Swiss-Prot 55.0 (Similarity)View   
3EPS15EP15_HUMANS485QHLQD S QQEIS 22.32% Swiss-Prot 55.0 View   
4EPS15EP15_HUMANS562ESPAR S SPELL 52.96% Swiss-Prot 55.0 (Similarity)View   
5EPS15EP15_HUMANS562ESPAR S SPELL 52.96% Phospho.ELM 7.0View   
6EPS15EP15_HUMANS563SPARS S PELLP 19.48% Swiss-Prot 55.0 (Similarity)View   
7EPS15EP15_HUMANS563SPARS S PELLP 19.48% Phospho.ELM 7.0View   
8EPS15EP15_HUMANT779KIGTP T RPCPL 47.26% Swiss-Prot 55.0 (Similarity)View   
9EPS15EP15_HUMANS814FPGND S PKEKD 41.70% Swiss-Prot 55.0 View   
10EPS15EP15_HUMANS814FPGND S PKEKD 41.70% Phospho.ELM 7.0View   
11EPS15EP15_HUMANY849ANFSA Y PSEED 13.19%EGFR  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
12EPS15EP15_HUMANY849ANFSA Y PSEED 13.19% Phospho.ELM 7.0View   
13EPS15EP15_HUMANY849ANFSA Y PSEED 13.19%EGFR HPRD:08968(in vitro;in vivo)  ViewAnalyzing