Regulatory Network in Protein Phosphorylation
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Substrate: GAB1

Description: GRB2-associated-binding protein 1 (Growth factor receptor boundprotein 2-associated protein 1) (GRB2-associated binder 1).

Ensembl ID: ENSG00000109458

UniprotKB/SwissProt: GAB1_HUMAN (Q13480)

Function: Probably involved in EGF and insulin receptor signaling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of GAB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1GAB1GAB1_HUMANY242QQQMI Y DSPPS 12.67%INSR HPRD:05116(in vitro)  ViewAnalyzing
2GAB1GAB1_HUMANY242QQQMI Y DSPPS 12.67%InsR Phospho.ELM 7.0  ViewAnalyzing
3GAB1GAB1_HUMANY259VDSSL Y NLPRS 19.32% Phospho.ELM 7.0View   
4GAB1GAB1_HUMANY259VDSSL Y NLPRS 19.32% Swiss-Prot 55.0 View   
5GAB1GAB1_HUMANY259VDSSL Y NLPRS 19.32% HPRD:05116(in vitro)View   
6GAB1GAB1_HUMANS266LPRSY S HDVLP 17.92% HPRD:05116(in vitro)View   
7GAB1GAB1_HUMANS266LPRSY S HDVLP 17.92% Swiss-Prot 55.0 View   
8GAB1GAB1_HUMANS266LPRSY S HDVLP 17.92% Phospho.ELM 7.0View   
9GAB1GAB1_HUMANY285ADGEL Y VFNTP 9.93%Met Phospho.ELM 7.0  ViewAnalyzing
10GAB1GAB1_HUMANY285ADGEL Y VFNTP 9.93%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
11GAB1GAB1_HUMANY285ADGEL Y VFNTP 9.93%INSR HPRD:05116(in vitro)  ViewAnalyzing
12GAB1GAB1_HUMANY285ADGEL Y VFNTP 9.93%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
13GAB1GAB1_HUMANY285ADGEL Y VFNTP 9.93%EGFR Phospho.ELM 7.0  ViewAnalyzing
14GAB1GAB1_HUMANY307HVSIS Y DIPPT 19.07%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
15GAB1GAB1_HUMANY307HVSIS Y DIPPT 19.07%EGFR Phospho.ELM 7.0  ViewAnalyzing
16GAB1GAB1_HUMANY307HVSIS Y DIPPT 19.07%Met Phospho.ELM 7.0  ViewAnalyzing
17GAB1GAB1_HUMANY307HVSIS Y DIPPT 19.07%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
18GAB1GAB1_HUMANT312YDIPP T PGNTY 38.17%Erk1 HPRD:05116(in vitro)  ViewAnalyzing
19GAB1GAB1_HUMANT312YDIPP T PGNTY 38.17%Erk2 HPRD:05116(in vitro)  ViewAnalyzing
20GAB1GAB1_HUMANY317TPGNT Y QIPRT 14.40% Phospho.ELM 7.0View   
21GAB1GAB1_HUMANY373DTDSS Y CIPTA 9.80%EGFR HPRD:05116(in vitro)  ViewAnalyzing
22GAB1GAB1_HUMANY373DTDSS Y CIPTA 9.80%Met Phospho.ELM 7.0  ViewAnalyzing
23GAB1GAB1_HUMANY373DTDSS Y CIPTA 9.80%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
24GAB1GAB1_HUMANY373DTDSS Y CIPTA 9.80%INSR HPRD:05116(in vitro)  ViewAnalyzing
25GAB1GAB1_HUMANY373DTDSS Y CIPTA 9.80%EGFR Phospho.ELM 7.0  ViewAnalyzing
26GAB1GAB1_HUMANY373DTDSS Y CIPTA 9.80%InsR Phospho.ELM 7.0  ViewAnalyzing
27GAB1GAB1_HUMANS381PTAGM S PSRSN 20.85%Erk1 HPRD:05116(in vitro)  ViewAnalyzing
28GAB1GAB1_HUMANS381PTAGM S PSRSN 20.85%Erk2 HPRD:05116(in vitro)  ViewAnalyzing
29GAB1GAB1_HUMANY406SSQDC Y DIPRA 25.79%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
30GAB1GAB1_HUMANY406SSQDC Y DIPRA 25.79%EGFR Phospho.ELM 7.0  ViewAnalyzing
31GAB1GAB1_HUMANY406SSQDC Y DIPRA 25.79%Met Phospho.ELM 7.0  ViewAnalyzing
32GAB1GAB1_HUMANY406SSQDC Y DIPRA 25.79%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
33GAB1GAB1_HUMANY447ELDEN Y VPMNP 12.13%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
34GAB1GAB1_HUMANY447ELDEN Y VPMNP 12.13%Met Phospho.ELM 7.0  ViewAnalyzing
35GAB1GAB1_HUMANY447ELDEN Y VPMNP 12.13%EGFR Phospho.ELM 7.0  ViewAnalyzing
36GAB1GAB1_HUMANY447ELDEN Y VPMNP 12.13%InsR Phospho.ELM 7.0  ViewAnalyzing
37GAB1GAB1_HUMANY447ELDEN Y VPMNP 12.13%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
38GAB1GAB1_HUMANY447ELDEN Y VPMNP 12.13%INSR HPRD:05116(in vitro)  ViewAnalyzing
39GAB1GAB1_HUMANS454PMNPN S PPRQH 37.22%Erk2 HPRD:05116(in vitro)  ViewAnalyzing
40GAB1GAB1_HUMANS454PMNPN S PPRQH 37.22%Erk1 HPRD:05116(in vitro)  ViewAnalyzing
41GAB1GAB1_HUMANY472IQEAN Y VPMTP 16.99%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
42GAB1GAB1_HUMANY472IQEAN Y VPMTP 16.99%EGFR Phospho.ELM 7.0  ViewAnalyzing
43GAB1GAB1_HUMANY472IQEAN Y VPMTP 16.99%InsR Phospho.ELM 7.0  ViewAnalyzing
44GAB1GAB1_HUMANY472IQEAN Y VPMTP 16.99%INSR HPRD:05116(in vitro)  ViewAnalyzing
45GAB1GAB1_HUMANY472IQEAN Y VPMTP 16.99%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
46GAB1GAB1_HUMANY472IQEAN Y VPMTP 16.99%Met Phospho.ELM 7.0  ViewAnalyzing
47GAB1GAB1_HUMANT476NYVPM T PGTFD 16.70%Erk2 HPRD:05116(in vitro)  ViewAnalyzing
48GAB1GAB1_HUMANT476NYVPM T PGTFD 16.70%Erk1 HPRD:05116(in vitro)  ViewAnalyzing
49GAB1GAB1_HUMANT476NYVPM T PGTFD 16.70%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
50GAB1GAB1_HUMANT503RSSPK T PPRRP 41.74% Swiss-Prot 55.0 (Similarity)View   
51GAB1GAB1_HUMANS551QAPVR S PITRS 22.38%Erk2 HPRD:05116(in vitro)  ViewAnalyzing
52GAB1GAB1_HUMANS551QAPVR S PITRS 22.38%Erk1 HPRD:05116(in vitro)  ViewAnalyzing
53GAB1GAB1_HUMANS567SRFPM S PRPDS 20.28%Erk1 HPRD:05116(in vitro)  ViewAnalyzing
54GAB1GAB1_HUMANS567SRFPM S PRPDS 20.28%Erk2 HPRD:05116(in vitro)  ViewAnalyzing
55GAB1GAB1_HUMANY589DSEEN Y VPMNP 14.81%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
56GAB1GAB1_HUMANY589DSEEN Y VPMNP 14.81%INSR HPRD:05116(in vitro)  ViewAnalyzing
57GAB1GAB1_HUMANY589DSEEN Y VPMNP 14.81%InsR Phospho.ELM 7.0  ViewAnalyzing
58GAB1GAB1_HUMANY589DSEEN Y VPMNP 14.81%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
59GAB1GAB1_HUMANY589DSEEN Y VPMNP 14.81%EGFR Phospho.ELM 7.0  ViewAnalyzing
60GAB1GAB1_HUMANY589DSEEN Y VPMNP 14.81%Met Phospho.ELM 7.0  ViewAnalyzing
61GAB1GAB1_HUMANS597MNPNL S SEDPN 38.02%Erk2 HPRD:05116(in vitro)  ViewAnalyzing
62GAB1GAB1_HUMANS597MNPNL S SEDPN 38.02%Erk1 HPRD:05116(in vitro)  ViewAnalyzing
63GAB1GAB1_HUMANY627DKQVE Y LDLDL 13.47%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
64GAB1GAB1_HUMANY627DKQVE Y LDLDL 13.47%Met Phospho.ELM 7.0  ViewAnalyzing
65GAB1GAB1_HUMANY627DKQVE Y LDLDL 13.47%INSR HPRD:05116(in vitro)  ViewAnalyzing
66GAB1GAB1_HUMANY627DKQVE Y LDLDL 13.47%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
67GAB1GAB1_HUMANY627DKQVE Y LDLDL 13.47%EGFR Phospho.ELM 7.0  ViewAnalyzing
68GAB1GAB1_HUMANY627DKQVE Y LDLDL 13.47%InsR Phospho.ELM 7.0  ViewAnalyzing
69GAB1GAB1_HUMANY659DERVD Y VVVDQ 7.71%EGFR HPRD:05116(in vitro;in vivo)  ViewAnalyzing
70GAB1GAB1_HUMANY659DERVD Y VVVDQ 7.71%MET HPRD:05116(in vitro;in vivo)  ViewAnalyzing
71GAB1GAB1_HUMANY659DERVD Y VVVDQ 7.71%EGFR Phospho.ELM 7.0  ViewAnalyzing
72GAB1GAB1_HUMANY659DERVD Y VVVDQ 7.71%INSR HPRD:05116(in vitro)  ViewAnalyzing
73GAB1GAB1_HUMANY659DERVD Y VVVDQ 7.71%Met Phospho.ELM 7.0  ViewAnalyzing