Regulatory Network in Protein Phosphorylation
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Substrate: HGS

Description: Hepatocyte growth factor-regulated tyrosine kinase substrate (Proteinpp110) (Hrs).

Synonyms: HRS

Ensembl ID: ENSG00000185359

UniprotKB/SwissProt: HGS_HUMAN (O14964)

Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Early endosome membrane; Peripheral membrane protein.
PDB:2D3G
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HGS

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HGSHGS_HUMANY216VCEPC Y EQLNR 19.88% Swiss-Prot 55.0 View   
2HGSHGS_HUMANY216VCEPC Y EQLNR 19.88% Phospho.ELM 7.0View   
3HGSHGS_HUMANY308PASSL Y SSPVN 14.73% Swiss-Prot 55.0 View   
4HGSHGS_HUMANY308PASSL Y SSPVN 14.73% HPRD:05085(in vivo)View   
5HGSHGS_HUMANY329PELAR Y LNRNY 11.61% Swiss-Prot 55.0 (Similarity)View   
6HGSHGS_HUMANY329PELAR Y LNRNY 11.61%EGFR HPRD:05085(in vitro)  ViewAnalyzing
7HGSHGS_HUMANY329PELAR Y LNRNY 11.61%EGFR Phospho.ELM 7.0  ViewAnalyzing
8HGSHGS_HUMANY334YLNRN Y WEKKQ 16.23% Swiss-Prot 55.0 (Similarity)View   
9HGSHGS_HUMANY334YLNRN Y WEKKQ 16.23% Phospho.ELM 7.0View   
10HGSHGS_HUMANY334YLNRN Y WEKKQ 16.23% HPRD:05085(in vitro)View