Regulatory Network in Protein Phosphorylation
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Substrate: RGS16

Description: Regulator of G-protein signaling 16 (RGS16) (Retinally abundantregulator of G-protein signaling) (RGS-R) (A28-RGS14P).

Synonyms: RGSR

Ensembl ID: ENSG00000143333

UniprotKB/SwissProt: RGS16_HUMAN (O15492)

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:2BT2
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RGS16

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RGS16RGS16_HUMANY168MEKDS Y PRFLK 14.46%Src Phospho.ELM 7.0  ViewAnalyzing
2RGS16RGS16_HUMANY168MEKDS Y PRFLK 14.46%EGFR Swiss-Prot 55.0   ViewAnalyzing
3RGS16RGS16_HUMANY168MEKDS Y PRFLK 14.46%CSK HPRD:03945(in vitro;in vivo)  ViewAnalyzing
4RGS16RGS16_HUMANY168MEKDS Y PRFLK 14.46%LYN HPRD:03945(in vitro;in vivo)  ViewAnalyzing
5RGS16RGS16_HUMANY168MEKDS Y PRFLK 14.46%EGFR Phospho.ELM 7.0  ViewAnalyzing
6RGS16RGS16_HUMANY168MEKDS Y PRFLK 14.46%EGFR HPRD:03945(in vitro;in vivo)  ViewAnalyzing
7RGS16RGS16_HUMANY168MEKDS Y PRFLK 14.46%SRC HPRD:03945(in vitro;in vivo)  ViewAnalyzing
8RGS16RGS16_HUMANY177LKSPA Y RDLAA 14.19%Lyn Phospho.ELM 7.0  ViewAnalyzing
9RGS16RGS16_HUMANY177LKSPA Y RDLAA 14.19%Src Phospho.ELM 7.0  ViewAnalyzing
10RGS16RGS16_HUMANY177LKSPA Y RDLAA 14.19%EGFR HPRD:03945(in vitro;in vivo)  ViewAnalyzing
11RGS16RGS16_HUMANY177LKSPA Y RDLAA 14.19%Src_group Phospho.ELM 7.0 ViewAnalyzing
12RGS16RGS16_HUMANY177LKSPA Y RDLAA 14.19% Swiss-Prot 55.0 View   
13RGS16RGS16_HUMANS195TLSSC S LDEPS 40.58% HPRD:03945(in vivo)View