Regulatory Network in Protein Phosphorylation
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Substrate: STAM2

Description: Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

Synonyms: HBP

Ensembl ID: ENSG00000115145

UniprotKB/SwissProt: STAM2_HUMAN (O75886)

Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
PDB:1X2Q
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STAM2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STAM2STAM2_HUMANY192ETKSL Y PSSEI 14.25% Swiss-Prot 55.0 View   
2STAM2STAM2_HUMANY192ETKSL Y PSSEI 14.25%EGFR Phospho.ELM 7.0  ViewAnalyzing
3STAM2STAM2_HUMANY192ETKSL Y PSSEI 14.25%EGFR HPRD:05876(in vitro;in vivo)  ViewAnalyzing
4STAM2STAM2_HUMANY371NEAPV Y SVYSK 7.43% HPRD:05876(in vitro)View   
5STAM2STAM2_HUMANY371NEAPV Y SVYSK 7.43% Phospho.ELM 7.0View   
6STAM2STAM2_HUMANY371NEAPV Y SVYSK 7.43% Swiss-Prot 55.0 View   
7STAM2STAM2_HUMANS372EAPVY S VYSKL 18.14% HPRD:05876(in vitro)View   
8STAM2STAM2_HUMANY374PVYSV Y SKLHP 8.31% Phospho.ELM 7.0View   
9STAM2STAM2_HUMANY374PVYSV Y SKLHP 8.31% Swiss-Prot 55.0 View   
10STAM2STAM2_HUMANY374PVYSV Y SKLHP 8.31% HPRD:05876(in vitro)View