Regulatory Network in Protein Phosphorylation
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Substrate: STAT5B

Description: Signal transducer and activator of transcription 5B.

Ensembl ID: ENSG00000173757

UniprotKB/SwissProt: STA5B_HUMAN (P51692)

Function: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of STAT5B

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1STAT5BSTA5B_HUMANY90IKLGH Y ATQLQ 15.00% Phospho.ELM 7.0View   
2STAT5BSTA5B_HUMANS193PLAQL S PQERL 16.68% Swiss-Prot 55.0 View   
3STAT5BSTA5B_HUMANY679PKDEV Y SKYYT 9.44%Src Phospho.ELM 7.0  ViewAnalyzing
4STAT5BSTA5B_HUMANY679PKDEV Y SKYYT 9.44%SRC HPRD:05037(in vitro;in vivo)  ViewAnalyzing
5STAT5BSTA5B_HUMANY699KAVDG Y VKPQI 10.80%HCK Phospho.ELM 7.0  ViewAnalyzing
6STAT5BSTA5B_HUMANY699KAVDG Y VKPQI 10.80%EGFR Phospho.ELM 7.0  ViewAnalyzing
7STAT5BSTA5B_HUMANY699KAVDG Y VKPQI 10.80%EGFR HPRD:05037(in vitro)  ViewAnalyzing
8STAT5BSTA5B_HUMANY699KAVDG Y VKPQI 10.80%JAK1 Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
9STAT5BSTA5B_HUMANY725GGSAT Y MDQAP 9.83%EGFR Phospho.ELM 7.0  ViewAnalyzing
10STAT5BSTA5B_HUMANY725GGSAT Y MDQAP 9.83%EGFR HPRD:05037(in vitro)  ViewAnalyzing
11STAT5BSTA5B_HUMANS731MDQAP S PAVCP 28.62% HPRD:05037(in vivo)View   
12STAT5BSTA5B_HUMANS731MDQAP S PAVCP 28.62% Phospho.ELM 7.0View   
13STAT5BSTA5B_HUMANY740CPQAH Y NMYPQ 12.49%EGFR HPRD:05037(in vitro)  ViewAnalyzing
14STAT5BSTA5B_HUMANY740CPQAH Y NMYPQ 12.49%EGFR Phospho.ELM 7.0  ViewAnalyzing
15STAT5BSTA5B_HUMANY743AHYNM Y PQNPD 9.68%EGFR HPRD:05037(in vitro)  ViewAnalyzing
16STAT5BSTA5B_HUMANY743AHYNM Y PQNPD 9.68%EGFR Phospho.ELM 7.0  ViewAnalyzing