Regulatory Network in Protein Phosphorylation
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Substrate: VIL2

Description: Ezrin (p81) (Cytovillin) (Villin-2).

Ensembl ID: ENSG00000092820

UniprotKB/SwissProt: EZRI_HUMAN (P15311)

Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
PDB:1NI2
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of VIL2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1VIL2EZRI_HUMANY146VHKSG Y LSSER 15.53%PDGFR_group Swiss-Prot 55.0  ViewAnalyzing
2VIL2EZRI_HUMANY146VHKSG Y LSSER 15.53%EGFR HPRD:00475(in vitro;in vivo)  ViewAnalyzing
3VIL2EZRI_HUMANY146VHKSG Y LSSER 15.53%EGFR Phospho.ELM 7.0  ViewAnalyzing
4VIL2EZRI_HUMANY146VHKSG Y LSSER 15.53%LCK HPRD:00475(in vitro;in vivo)  ViewAnalyzing
5VIL2EZRI_HUMANY146VHKSG Y LSSER 15.53%Lck Phospho.ELM 7.0  ViewAnalyzing
6VIL2EZRI_HUMANT235KDDKL T PKIGF 28.42%CDK5 HPRD:00475(in vitro;in vivo)  ViewAnalyzing
7VIL2EZRI_HUMANY354LRLQD Y EEKTK 17.02%PDGFR_group Swiss-Prot 55.0  ViewAnalyzing
8VIL2EZRI_HUMANY354LRLQD Y EEKTK 17.02%EGFR Phospho.ELM 7.0  ViewAnalyzing
9VIL2EZRI_HUMANY354LRLQD Y EEKTK 17.02%EGFR HPRD:00475(in vitro)  ViewAnalyzing
10VIL2EZRI_HUMANY478PPPPV Y EPVSY 21.93%Src Phospho.ELM 7.0  ViewAnalyzing
11VIL2EZRI_HUMANT567RDKYK T LRQIR 24.88%PKCa HPRD:00475(in vivo)  ViewAnalyzing
12VIL2EZRI_HUMANT567RDKYK T LRQIR 24.88%ROCK1 HPRD:00475(in vivo)  ViewAnalyzing
13VIL2EZRI_HUMANT567RDKYK T LRQIR 24.88%ROCK1 Phospho.ELM 7.0  ViewAnalyzing
14VIL2EZRI_HUMANT567RDKYK T LRQIR 24.88%BARK1(GRK2) Phospho.ELM 7.0 ViewAnalyzing
15VIL2EZRI_HUMANT567RDKYK T LRQIR 24.88%Akt2(PKB beta) Phospho.ELM 7.0 ViewAnalyzing