Regulatory Network in Protein Phosphorylation
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Substrate: EPHB2

Description: Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-proteinkinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5)(ERK) (Tyrosine-protein kinase TYRO5) (Renal carcinoma antigen NY-REN-47).

Synonyms: DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5

Ensembl ID: ENSG00000133216

UniprotKB/SwissProt: EPHB2_HUMAN (P29323)

Function: Receptor for members of the ephrin-B family. Acts as a tumor suppressor.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1B4F
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EPHB2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EPHB2EPHB2_HUMANY577RADSE Y TDKLQ 24.96% HPRD:02997(in vivo)View   
2EPHB2EPHB2_HUMANY584DKLQH Y TSGHM 6.94% HPRD:02997(in vivo)View   
3EPHB2EPHB2_HUMANY596PGMKI Y IDPFT 8.18%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing
4EPHB2EPHB2_HUMANY596PGMKI Y IDPFT 8.18% HPRD:02997(in vivo)View   
5EPHB2EPHB2_HUMANY602IDPFT Y EDPNE 20.79%EphB2 HPRD:02997(in vivo)  ViewAnalyzing
6EPHB2EPHB2_HUMANY602IDPFT Y EDPNE 20.79%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing
7EPHB2EPHB2_HUMANY602IDPFT Y EDPNE 20.79%EphB2 HPRD:02997(in vitro;in vivo)  ViewAnalyzing
8EPHB2EPHB2_HUMANY659TLKSG Y TEKQR 20.86% HPRD:02997(in vivo)View   
9EPHB2EPHB2_HUMANY736AAGMK Y LADMN 9.76% HPRD:02997(in vivo)View   
10EPHB2EPHB2_HUMANY742LADMN Y VHRDL 7.32% HPRD:02997(in vivo)View   
11EPHB2EPHB2_HUMANT775FLEDD T SDPTY 47.56% Phospho.ELM 7.0View   
12EPHB2EPHB2_HUMANT775FLEDD T SDPTY 47.56% Swiss-Prot 55.0 View   
13EPHB2EPHB2_HUMANY780TSDPT Y TSALG 12.23% HPRD:02997(in vivo)View   
14EPHB2EPHB2_HUMANY780TSDPT Y TSALG 12.23%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing
15EPHB2EPHB2_HUMANY800PEAIQ Y RKFTS 15.06% HPRD:02997(in vivo)View   
16EPHB2EPHB2_HUMANY930IKMGQ Y KESFA 15.82% HPRD:02997(in vivo)View   
17EPHB2EPHB2_HUMANY930IKMGQ Y KESFA 15.82%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
18EPHB2EPHB2_HUMANY930IKMGQ Y KESFA 15.82% HPRD:02997(in vivo)View