Regulatory Network in Protein Phosphorylation
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Substrate: EPHA3

Description: Ephrin type-A receptor 3 precursor (EC (Tyrosine-proteinkinase receptor ETK1) (HEK) (HEK4) (Tyrosine-protein kinase TYRO4).

Synonyms: ETK, ETK1, HEK, TYRO4

Ensembl ID: ENSG00000044524

UniprotKB/SwissProt: EPHA3_HUMAN (P29320)

Function: Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EPHA3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EPHA3EPHA3_HUMANY596PGLRT Y VDPHT 9.09%EphA3 Phospho.ELM 7.0  ViewAnalyzing
2EPHA3EPHA3_HUMANY596PGLRT Y VDPHT 9.09%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing
3EPHA3EPHA3_HUMANY596PGLRT Y VDPHT 9.09%EphA3 HPRD:01555(in vitro)  ViewAnalyzing
4EPHA3EPHA3_HUMANY602VDPHT Y EDPTQ 18.46%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing
5EPHA3EPHA3_HUMANY602VDPHT Y EDPTQ 18.46%EphA3 Phospho.ELM 7.0  ViewAnalyzing
6EPHA3EPHA3_HUMANY602VDPHT Y EDPTQ 18.46%EphA3 HPRD:01555(in vitro)  ViewAnalyzing
7EPHA3EPHA3_HUMANY779DPEAA Y TTRGG 18.72%EphA3 HPRD:01555(in vitro)  ViewAnalyzing
8EPHA3EPHA3_HUMANY779DPEAA Y TTRGG 18.72%EphA3 Phospho.ELM 7.0  ViewAnalyzing
9EPHA3EPHA3_HUMANY779DPEAA Y TTRGG 18.72%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
10EPHA3EPHA3_HUMANY937FTGVE Y SSCDT 11.95% Swiss-Prot 55.0 (Similarity)View