Regulatory Network in Protein Phosphorylation
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Substrate: EPHA4

Description: Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-proteinkinase receptor SEK) (Receptor protein-tyrosine kinase HEK8)(Tyrosine-protein kinase TYRO1).

Synonyms: HEK8, SEK, TYRO1

Ensembl ID: ENSG00000116106

UniprotKB/SwissProt: EPHA4_HUMAN (P54764)

Function: Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EPHA4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EPHA4EPHA4_HUMANY596QGVRT Y VDPFT 7.71%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2EPHA4EPHA4_HUMANY596QGVRT Y VDPFT 7.71%EphA4 HPRD:03719(in vitro)  ViewAnalyzing
3EPHA4EPHA4_HUMANY596QGVRT Y VDPFT 7.71%EphA4 Phospho.ELM 7.0  ViewAnalyzing
4EPHA4EPHA4_HUMANY602VDPFT Y EDPNQ 20.79%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
5EPHA4EPHA4_HUMANY602VDPFT Y EDPNQ 20.79%EphA4 HPRD:03719(in vitro)  ViewAnalyzing
6EPHA4EPHA4_HUMANY602VDPFT Y EDPNQ 20.79%EphA4 Phospho.ELM 7.0  ViewAnalyzing
7EPHA4EPHA4_HUMANY779DPEAA Y TTRGG 18.72%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing
8EPHA4EPHA4_HUMANY928IKMDR Y KDNFT 20.59%autocatalysis  Swiss-Prot 55.0 (Potential) ViewAnalyzing