Regulatory Network in Protein Phosphorylation
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Substrate: AURKA

Description: Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora kinase A)(Aurora-A) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1)(Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase).

Synonyms: AIK, ARK1, AURA, BTAK, STK15, STK6

Ensembl ID: ENSG00000087586

UniprotKB/SwissProt: STK6_HUMAN (O14965)

Function: May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Maybe involved in microtubule formation and/or stabilization. May play a key role during tumor development and progression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Centrosome. Spindle. Note=Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.
PDB:1MQ4
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of AURKA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1AURKASTK6_HUMANS10KENCI S GPVKA 38.96%AurA Phospho.ELM 7.0  ViewAnalyzing
2AURKASTK6_HUMANT16GPVKA T APVGG 26.27%AurA Phospho.ELM 7.0  ViewAnalyzing
3AURKASTK6_HUMANS41PLPVN S GQAQR 32.30%AurA Phospho.ELM 7.0  ViewAnalyzing
4AURKASTK6_HUMANS67QKLVS S HKPVQ 28.22%AurA Phospho.ELM 7.0  ViewAnalyzing
5AURKASTK6_HUMANS83QLQAT S VPHPV 36.35%AurA Phospho.ELM 7.0  ViewAnalyzing
6AURKASTK6_HUMANS98NNTQK S KQPLP 27.06%AurA Phospho.ELM 7.0  ViewAnalyzing
7AURKASTK6_HUMANS104KQPLP S APENN 65.23%AurA Phospho.ELM 7.0  ViewAnalyzing
8AURKASTK6_HUMANY148KFGNV Y LAREK 9.92% Phospho.ELM 7.0View   
9AURKASTK6_HUMANS226ELQKL S KFDEQ 38.01%AurA Phospho.ELM 7.0  ViewAnalyzing
10AURKASTK6_HUMANS266NLLLG S AGELK 32.82%AurA Phospho.ELM 7.0  ViewAnalyzing
11AURKASTK6_HUMANS278ADFGW S VHAPS 12.38%AurA Phospho.ELM 7.0  ViewAnalyzing
12AURKASTK6_HUMANT287PSSRR T TLCGT 24.02%AurA Phospho.ELM 7.0  ViewAnalyzing
13AURKASTK6_HUMANT288SSRRT T LCGTL 20.45%PKA_group Phospho.ELM 7.0 ViewAnalyzing
14AURKASTK6_HUMANT288SSRRT T LCGTL 20.45%PKACa HPRD:04066(in vitro)  ViewAnalyzing
15AURKASTK6_HUMANT288SSRRT T LCGTL 20.45%AurA Phospho.ELM 7.0  ViewAnalyzing
16AURKASTK6_HUMANS342TYKRI S RVEFT 34.02%AurA Phospho.ELM 7.0  ViewAnalyzing
17AURKASTK6_HUMANS369LKHNP S QRPML 44.10% Swiss-Prot 55.0 View   
18AURKASTK6_HUMANS391NSSKP S NCQNK 54.71%AurA Phospho.ELM 7.0  ViewAnalyzing