|Description: Serine/threonine-protein kinase 12 (EC 126.96.36.199) (Aurora-B) (Aurora-and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1).|
Synonyms: AIK2, AIM1, ARK2, STK12
Ensembl ID: ENSG00000178999
UniprotKB/SwissProt: AURKB_HUMAN (Q96GD4)
Function: May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid- body.