Regulatory Network in Protein Phosphorylation
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Substrate: CDC25B

Description: M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificityphosphatase Cdc25B).

Synonyms: CDC25HU2

Ensembl ID: ENSG00000101224

UniprotKB/SwissProt: MPIP2_HUMAN (P30305)

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Centrosome.
PDB:1CWR
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDC25B

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDC25BMPIP2_HUMANS160RLLGH S PVLRN 18.20%CDC2 HPRD:00307(in vitro)  ViewAnalyzing
2CDC25BMPIP2_HUMANS160RLLGH S PVLRN 18.20%CDC2(CDK1) Phospho.ELM 7.0 ViewAnalyzing
3CDC25BMPIP2_HUMANS169RNITN S QAPDG 21.04%MELK(pEg3 kinase) Phospho.ELM 7.0 ViewAnalyzing
4CDC25BMPIP2_HUMANS186GSGAA S SSGED 25.22%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
5CDC25BMPIP2_HUMANS186GSGAA S SSGED 25.22%CK2_group Phospho.ELM 7.0 ViewAnalyzing
6CDC25BMPIP2_HUMANS186GSGAA S SSGED 25.22%CK2a1 HPRD:00307(in vitro;in vivo)  ViewAnalyzing
7CDC25BMPIP2_HUMANS186GSGAA S SSGED 25.22%CK2a1-rs HPRD:00307(in vitro;in vivo)  ViewAnalyzing
8CDC25BMPIP2_HUMANS187SGAAS S SGEDK 37.32%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9CDC25BMPIP2_HUMANS187SGAAS S SGEDK 37.32%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
10CDC25BMPIP2_HUMANS187SGAAS S SGEDK 37.32%CK2a1 HPRD:00307(in vitro;in vivo)  ViewAnalyzing
11CDC25BMPIP2_HUMANS187SGAAS S SGEDK 37.32%CK2a1-rs HPRD:00307(in vitro;in vivo)  ViewAnalyzing
12CDC25BMPIP2_HUMANS321QRLFR S PSMPC 17.62%MELK HPRD:00307(in vitro)  ViewAnalyzing
13CDC25BMPIP2_HUMANS323LFRSP S MPCSV 36.28%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
14CDC25BMPIP2_HUMANS353NKRRR S VTPPE 28.65%MELK(pEg3 kinase) Phospho.ELM 7.0 ViewAnalyzing
15CDC25BMPIP2_HUMANS353NKRRR S VTPPE 28.65%AurA HPRD:00307(in vitro;in vivo)  ViewAnalyzing
16CDC25BMPIP2_HUMANS353NKRRR S VTPPE 28.65%AurA Phospho.ELM 7.0  ViewAnalyzing
17CDC25BMPIP2_HUMANS375VLRSK S LCHDE 37.16%BRSK1 Phospho.ELM 7.0  ViewAnalyzing