Regulatory Network in Protein Phosphorylation
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Substrate: H3F3A

Description: Histone H3.3.

Synonyms: H3.3A, H3F3

Ensembl ID: ENSG00000132475

UniprotKB/SwissProt: H33_HUMAN (P84243)

Function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of H3F3A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1H3F3AH33_HUMANT4--MAR T KQTAR 20.26% Swiss-Prot 55.0 View   
2H3F3AH33_HUMANS11QTARK S TGGKA 27.08% Swiss-Prot 55.0 View   
3H3F3AH33_HUMANS11QTARK S TGGKA 27.08%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
4H3F3AH33_HUMANS11QTARK S TGGKA 27.08% HPRD:03082(in vitro)View   
5H3F3AH33_HUMANT12TARKS T GGKAP 53.65% Swiss-Prot 55.0 View   
6H3F3AH33_HUMANS29KAARK S APSTG 39.60%JNK2 HPRD:03082(in vitro)  ViewAnalyzing
7H3F3AH33_HUMANS29KAARK S APSTG 39.60%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
8H3F3AH33_HUMANS29KAARK S APSTG 39.60% Swiss-Prot 55.0 View   
9H3F3AH33_HUMANS32RKSAP S TGGVK 39.13% Swiss-Prot 55.0 View   
10H3F3AH33_HUMANS32RKSAP S TGGVK 39.13% Phospho.ELM 7.0View