Regulatory Network in Protein Phosphorylation
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Substrate: HIST1H3A

Description: Histone H3.1 (H3/a) (H3/b) (H3/c) (H3/d) (H3/f) (H3/h) (H3/i) (H3/j)(H3/k) (H3/l).

Synonyms: H3FA

Ensembl ID: ENSG00000112727

UniprotKB/SwissProt: H31_HUMAN (P68431)

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HIST1H3A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HIST1H3AH31_HUMANT4--MAR T KQTAR 20.26% Swiss-Prot 55.0 View   
2HIST1H3AH31_HUMANS11QTARK S TGGKA 27.08% Swiss-Prot 55.0 View   
3HIST1H3AH31_HUMANS11QTARK S TGGKA 27.08%AurA Phospho.ELM 7.0  ViewAnalyzing
4HIST1H3AH31_HUMANS11QTARK S TGGKA 27.08%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
5HIST1H3AH31_HUMANT12TARKS T GGKAP 53.65% Swiss-Prot 55.0 View   
6HIST1H3AH31_HUMANT12TARKS T GGKAP 53.65%DAPK3 Phospho.ELM 7.0  ViewAnalyzing
7HIST1H3AH31_HUMANS29KAARK S APATG 33.65% Swiss-Prot 55.0 View   
8HIST1H3AH31_HUMANS29KAARK S APATG 33.65%MAPK_group Phospho.ELM 7.0 ViewAnalyzing
9HIST1H3AH31_HUMANS29KAARK S APATG 33.65%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing