Regulatory Network in Protein Phosphorylation
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Substrate: INCENP

Description: Inner centromere protein.

Ensembl ID: ENSG00000149503

UniprotKB/SwissProt: INCE_HUMAN (Q9NQS7)

Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Centromere. Spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
PDB:2QFA
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of INCENP

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1INCENPINCE_HUMANY73KRRIS Y VQDEN 10.35% Swiss-Prot 55.0 View   
2INCENPINCE_HUMANY73KRRIS Y VQDEN 10.35% HPRD:05103(in vivo)View   
3INCENPINCE_HUMANY73KRRIS Y VQDEN 10.35% Phospho.ELM 7.0View   
4INCENPINCE_HUMANS119VGENG S VLRRV 29.56% Swiss-Prot 55.0 View   
5INCENPINCE_HUMANS119VGENG S VLRRV 29.56% Phospho.ELM 7.0View   
6INCENPINCE_HUMANS119VGENG S VLRRV 29.56% HPRD:05103(in vivo)View   
7INCENPINCE_HUMANS142ALAAP S SPTPE 44.19% Phospho.ELM 7.0View   
8INCENPINCE_HUMANS142ALAAP S SPTPE 44.19% Swiss-Prot 55.0 View   
9INCENPINCE_HUMANS143LAAPS S PTPES 31.56% Phospho.ELM 7.0View   
10INCENPINCE_HUMANS143LAAPS S PTPES 31.56% HPRD:05103(in vivo)View   
11INCENPINCE_HUMANS143LAAPS S PTPES 31.56% Swiss-Prot 55.0 View   
12INCENPINCE_HUMANS148SPTPE S PTMLT 27.20% Swiss-Prot 55.0 View   
13INCENPINCE_HUMANS148SPTPE S PTMLT 27.20% Phospho.ELM 7.0View   
14INCENPINCE_HUMANS197LPRTL S PTPAS 26.56% Swiss-Prot 55.0 View   
15INCENPINCE_HUMANS197LPRTL S PTPAS 26.56% Phospho.ELM 7.0View   
16INCENPINCE_HUMANS197LPRTL S PTPAS 26.56% HPRD:05103(in vivo)View   
17INCENPINCE_HUMANT199RTLSP T PASAT 28.28% HPRD:05103(in vivo)View   
18INCENPINCE_HUMANT199RTLSP T PASAT 28.28% Swiss-Prot 55.0 View   
19INCENPINCE_HUMANT199RTLSP T PASAT 28.28% Phospho.ELM 7.0View   
20INCENPINCE_HUMANT213SQGIP T SDEES 47.06% Phospho.ELM 7.0View   
21INCENPINCE_HUMANT213SQGIP T SDEES 47.06% HPRD:05103(in vivo)View   
22INCENPINCE_HUMANT213SQGIP T SDEES 47.06% Swiss-Prot 55.0 View   
23INCENPINCE_HUMANS214QGIPT S DEEST 37.36% Phospho.ELM 7.0View   
24INCENPINCE_HUMANS214QGIPT S DEEST 37.36% Swiss-Prot 55.0 View   
25INCENPINCE_HUMANS214QGIPT S DEEST 37.36% HPRD:05103(in vivo)View   
26INCENPINCE_HUMANT219SDEES T PKKSK 42.27% Phospho.ELM 7.0View   
27INCENPINCE_HUMANT219SDEES T PKKSK 42.27% HPRD:05103(in vivo)View   
28INCENPINCE_HUMANT219SDEES T PKKSK 42.27% Swiss-Prot 55.0 View   
29INCENPINCE_HUMANS230ARILE S ITVSS 21.80% Swiss-Prot 55.0 View   
30INCENPINCE_HUMANS230ARILE S ITVSS 21.80% HPRD:05103(in vivo)View   
31INCENPINCE_HUMANS230ARILE S ITVSS 21.80% Phospho.ELM 7.0View   
32INCENPINCE_HUMANT239SSLMA T PQDPK 13.91% Phospho.ELM 7.0View   
33INCENPINCE_HUMANT239SSLMA T PQDPK 13.91% HPRD:05103(in vivo)View   
34INCENPINCE_HUMANT239SSLMA T PQDPK 13.91% Swiss-Prot 55.0 View   
35INCENPINCE_HUMANS263RIAQV S PGPRD 16.44% HPRD:05103(in vivo)View   
36INCENPINCE_HUMANS263RIAQV S PGPRD 16.44% Phospho.ELM 7.0View   
37INCENPINCE_HUMANS263RIAQV S PGPRD 16.44% Swiss-Prot 55.0 View   
38INCENPINCE_HUMANS269PGPRD S PAFPD 21.29% Swiss-Prot 55.0 View   
39INCENPINCE_HUMANS269PGPRD S PAFPD 21.29% Phospho.ELM 7.0View   
40INCENPINCE_HUMANS269PGPRD S PAFPD 21.29% HPRD:05103(in vivo)View   
41INCENPINCE_HUMANS275PAFPD S PWRER 26.97% Phospho.ELM 7.0View   
42INCENPINCE_HUMANS275PAFPD S PWRER 26.97% HPRD:05103(in vivo)View   
43INCENPINCE_HUMANS275PAFPD S PWRER 26.97% Swiss-Prot 55.0 View   
44INCENPINCE_HUMANS291LPDNF S TPTGS 39.47% HPRD:05103(in vivo)View   
45INCENPINCE_HUMANS291LPDNF S TPTGS 39.47% Swiss-Prot 55.0 View   
46INCENPINCE_HUMANS291LPDNF S TPTGS 39.47% Phospho.ELM 7.0View   
47INCENPINCE_HUMANT292PDNFS T PTGSR 22.26% Phospho.ELM 7.0View   
48INCENPINCE_HUMANT292PDNFS T PTGSR 22.26% HPRD:05103(in vivo)View   
49INCENPINCE_HUMANT292PDNFS T PTGSR 22.26% Swiss-Prot 55.0 View   
50INCENPINCE_HUMANT294NFSTP T GSRTD 48.13% Swiss-Prot 55.0 View   
51INCENPINCE_HUMANT294NFSTP T GSRTD 48.13% HPRD:05103(in vivo)View   
52INCENPINCE_HUMANT294NFSTP T GSRTD 48.13% Phospho.ELM 7.0View   
53INCENPINCE_HUMANS296STPTG S RTDSQ 34.19% Phospho.ELM 7.0View   
54INCENPINCE_HUMANS296STPTG S RTDSQ 34.19% Swiss-Prot 55.0 View   
55INCENPINCE_HUMANS296STPTG S RTDSQ 34.19% HPRD:05103(in vivo)View   
56INCENPINCE_HUMANT298PTGSR T DSQSV 41.52% Swiss-Prot 55.0 View   
57INCENPINCE_HUMANS306QSVRH S PIAPS 13.87% Swiss-Prot 55.0 View   
58INCENPINCE_HUMANS306QSVRH S PIAPS 13.87% HPRD:05103(in vivo)View   
59INCENPINCE_HUMANS306QSVRH S PIAPS 13.87% Phospho.ELM 7.0View   
60INCENPINCE_HUMANS312PIAPS S PSPQV 28.47% HPRD:05103(in vivo)View   
61INCENPINCE_HUMANS312PIAPS S PSPQV 28.47% Swiss-Prot 55.0 View   
62INCENPINCE_HUMANS312PIAPS S PSPQV 28.47% Phospho.ELM 7.0View   
63INCENPINCE_HUMANS314APSSP S PQVLA 29.88% Phospho.ELM 7.0View   
64INCENPINCE_HUMANS314APSSP S PQVLA 29.88% Swiss-Prot 55.0 View   
65INCENPINCE_HUMANS314APSSP S PQVLA 29.88% HPRD:05103(in vivo)View   
66INCENPINCE_HUMANS421KPAAS S PETPS 23.25% Swiss-Prot 55.0 View   
67INCENPINCE_HUMANS421KPAAS S PETPS 23.25% Phospho.ELM 7.0View   
68INCENPINCE_HUMANS421KPAAS S PETPS 23.25% HPRD:05103(in vivo)View   
69INCENPINCE_HUMANT424ASSPE T PSAGQ 26.40% Swiss-Prot 55.0 View   
70INCENPINCE_HUMANT424ASSPE T PSAGQ 26.40% HPRD:05103(in vivo)View   
71INCENPINCE_HUMANT424ASSPE T PSAGQ 26.40% Phospho.ELM 7.0View   
72INCENPINCE_HUMANS481SKTPS S PCPAS 31.55% Phospho.ELM 7.0View   
73INCENPINCE_HUMANS481SKTPS S PCPAS 31.55% Swiss-Prot 55.0 View   
74INCENPINCE_HUMANS481SKTPS S PCPAS 31.55% HPRD:05103(in vivo)View   
75INCENPINCE_HUMANS833GMDLN S DDSTD 50.52% HPRD:05103(in vivo)View   
76INCENPINCE_HUMANS833GMDLN S DDSTD 50.52% Swiss-Prot 55.0 View   
77INCENPINCE_HUMANS833GMDLN S DDSTD 50.52% Phospho.ELM 7.0View   
78INCENPINCE_HUMANS836LNSDD S TDDEA 38.43% HPRD:05103(in vivo)View   
79INCENPINCE_HUMANS836LNSDD S TDDEA 38.43% Swiss-Prot 55.0 View   
80INCENPINCE_HUMANS836LNSDD S TDDEA 38.43% Phospho.ELM 7.0View   
81INCENPINCE_HUMANT837NSDDS T DDEAH 55.23% Swiss-Prot 55.0 View   
82INCENPINCE_HUMANT837NSDDS T DDEAH 55.23% Phospho.ELM 7.0View   
83INCENPINCE_HUMANT837NSDDS T DDEAH 55.23% HPRD:05103(in vivo)View   
84INCENPINCE_HUMANS889DIFKK S KPRYH 48.78%AurB HPRD:05103(in vitro)  ViewAnalyzing
85INCENPINCE_HUMANT897RYHKR T SSAVW 31.66%AurB HPRD:05103(in vitro)  ViewAnalyzing
86INCENPINCE_HUMANT897RYHKR T SSAVW 31.66% Swiss-Prot 55.0 View   
87INCENPINCE_HUMANT897RYHKR T SSAVW 31.66%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
88INCENPINCE_HUMANS898YHKRT S SAVWN 21.97%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
89INCENPINCE_HUMANS898YHKRT S SAVWN 21.97% Swiss-Prot 55.0 View   
90INCENPINCE_HUMANS899HKRTS S AVWNS 26.65% Swiss-Prot 55.0 View   
91INCENPINCE_HUMANS899HKRTS S AVWNS 26.65%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
92INCENPINCE_HUMANS899HKRTS S AVWNS 26.65%AurB HPRD:05103(in vitro;in vivo)  ViewAnalyzing
93INCENPINCE_HUMANS904SAVWN S PPLQG 16.51% Swiss-Prot 55.0 View   
94INCENPINCE_HUMANS904SAVWN S PPLQG 16.51% HPRD:05103(in vivo)View