Regulatory Network in Protein Phosphorylation
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Substrate: RACGAP1

Description: Rac GTPase-activating protein 1 (MgcRacGAP).

Synonyms: KIAA1478, MGCRACGAP

Ensembl ID: ENSG00000161800

UniprotKB/SwissProt: RGAP1_HUMAN (Q9H0H5)

Function: Essential for the early stages of embryogenesis and may play a role in the microtubule-dependent steps in cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Required for initiation of cleavage furrow ingression by regulating ECT2 and for assembly of the contractile ring. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Spindle. Acrosome. Note=During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody. Colocalizes with RHOA a
PDB:2OVJ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RACGAP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RACGAP1RGAP1_HUMANS144GNKRL S TIDES 27.61%AurB HPRD:05402(in vitro)  ViewAnalyzing
2RACGAP1RGAP1_HUMANT145NKRLS T IDESG 36.72%AurB HPRD:05402(in vitro)  ViewAnalyzing
3RACGAP1RGAP1_HUMANT161ISFDK T DESLD 47.01% Swiss-Prot 55.0 View   
4RACGAP1RGAP1_HUMANT161ISFDK T DESLD 47.01% HPRD:05402(in vivo)View   
5RACGAP1RGAP1_HUMANT161ISFDK T DESLD 47.01% Phospho.ELM 7.0View   
6RACGAP1RGAP1_HUMANS164DKTDE S LDWDS 34.14% Phospho.ELM 7.0View   
7RACGAP1RGAP1_HUMANS164DKTDE S LDWDS 34.14% HPRD:05402(in vivo)View   
8RACGAP1RGAP1_HUMANS164DKTDE S LDWDS 34.14% Swiss-Prot 55.0 View   
9RACGAP1RGAP1_HUMANS170LDWDS S LVKTF 34.41% Phospho.ELM 7.0View   
10RACGAP1RGAP1_HUMANS170LDWDS S LVKTF 34.41% HPRD:05402(in vivo)View   
11RACGAP1RGAP1_HUMANS170LDWDS S LVKTF 34.41% Swiss-Prot 55.0 View   
12RACGAP1RGAP1_HUMANS185REKRR S TSRQF 34.46%AurB HPRD:05402(in vitro)  ViewAnalyzing
13RACGAP1RGAP1_HUMANS185REKRR S TSRQF 34.46% Swiss-Prot 55.0 View   
14RACGAP1RGAP1_HUMANT186EKRRS T SRQFV 26.56%AurB HPRD:05402(in vitro)  ViewAnalyzing
15RACGAP1RGAP1_HUMANS187KRRST S RQFVD 25.90% Swiss-Prot 55.0 View   
16RACGAP1RGAP1_HUMANS187KRRST S RQFVD 25.90%AurB HPRD:05402(in vitro)  ViewAnalyzing
17RACGAP1RGAP1_HUMANS203VKKTR S IGSAV 36.21% HPRD:05402(in vivo)View   
18RACGAP1RGAP1_HUMANS203VKKTR S IGSAV 36.21% Phospho.ELM 7.0View   
19RACGAP1RGAP1_HUMANS203VKKTR S IGSAV 36.21% Swiss-Prot 55.0 View   
20RACGAP1RGAP1_HUMANS206TRSIG S AVDQG 24.37% Swiss-Prot 55.0 View   
21RACGAP1RGAP1_HUMANS206TRSIG S AVDQG 24.37% Phospho.ELM 7.0View   
22RACGAP1RGAP1_HUMANS214DQGNE S IVAKT 26.77% HPRD:05402(in vivo)View   
23RACGAP1RGAP1_HUMANS214DQGNE S IVAKT 26.77% Phospho.ELM 7.0View   
24RACGAP1RGAP1_HUMANS214DQGNE S IVAKT 26.77% Swiss-Prot 55.0 View   
25RACGAP1RGAP1_HUMANT342PTLIG T PVKIG 20.22% HPRD:05402(in vivo)View   
26RACGAP1RGAP1_HUMANT342PTLIG T PVKIG 20.22% Swiss-Prot 55.0 View   
27RACGAP1RGAP1_HUMANT342PTLIG T PVKIG 20.22% Phospho.ELM 7.0View   
28RACGAP1RGAP1_HUMANS387GLYRI S GCDRT 25.11% Swiss-Prot 55.0 View   
29RACGAP1RGAP1_HUMANS387GLYRI S GCDRT 25.11%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
30RACGAP1RGAP1_HUMANS387GLYRI S GCDRT 25.11%AurB HPRD:05402(in vitro;in vivo)  ViewAnalyzing
31RACGAP1RGAP1_HUMANS410TVPLL S KVDDI 38.01%AurB HPRD:05402(in vitro)  ViewAnalyzing
32RACGAP1RGAP1_HUMANS410TVPLL S KVDDI 38.01%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
33RACGAP1RGAP1_HUMANT580LGPVT T PEHQL 27.24% Swiss-Prot 55.0 View   
34RACGAP1RGAP1_HUMANT580LGPVT T PEHQL 27.24% HPRD:05402(in vivo)View   
35RACGAP1RGAP1_HUMANT580LGPVT T PEHQL 27.24% Phospho.ELM 7.0View   
36RACGAP1RGAP1_HUMANT588HQLLK T PSSSS 28.51% HPRD:05402(in vivo)View   
37RACGAP1RGAP1_HUMANT588HQLLK T PSSSS 28.51% Phospho.ELM 7.0View   
38RACGAP1RGAP1_HUMANT588HQLLK T PSSSS 28.51% Swiss-Prot 55.0 View   
39RACGAP1RGAP1_HUMANS590LLKTP S SSSLS 48.35% HPRD:05402(in vivo)View   
40RACGAP1RGAP1_HUMANS590LLKTP S SSSLS 48.35% Swiss-Prot 55.0 View   
41RACGAP1RGAP1_HUMANS590LLKTP S SSSLS 48.35% Phospho.ELM 7.0View   
42RACGAP1RGAP1_HUMANT606TLTKN T PRFGS 19.87% Swiss-Prot 55.0 View   
43RACGAP1RGAP1_HUMANS628GNFFA S PMLK 12.99% HPRD:05402(in vivo)View   
44RACGAP1RGAP1_HUMANS628GNFFA S PMLK 12.99% Phospho.ELM 7.0View   
45RACGAP1RGAP1_HUMANS628GNFFA S PMLK 12.99% Swiss-Prot 55.0 View