Regulatory Network in Protein Phosphorylation
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Substrate: AURKA

Description: Serine/threonine-protein kinase 6 (EC (Aurora kinase A)(Aurora-A) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1)(Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase).

Synonyms: AIK, ARK1, AURA, BTAK, STK15, STK6

Ensembl ID: ENSG00000087586

UniprotKB/SwissProt: STK6_HUMAN (O14965)

Function: May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Maybe involved in microtubule formation and/or stabilization. May play a key role during tumor development and progression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Centrosome. Spindle. Note=Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of AURKA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1AURKASTK6_HUMANS10KENCI S GPVKA 38.96%AurA Phospho.ELM 7.0  ViewAnalyzing
2AURKASTK6_HUMANT16GPVKA T APVGG 26.27%AurA Phospho.ELM 7.0  ViewAnalyzing
3AURKASTK6_HUMANS41PLPVN S GQAQR 32.30%AurA Phospho.ELM 7.0  ViewAnalyzing
4AURKASTK6_HUMANS67QKLVS S HKPVQ 28.22%AurA Phospho.ELM 7.0  ViewAnalyzing
5AURKASTK6_HUMANS83QLQAT S VPHPV 36.35%AurA Phospho.ELM 7.0  ViewAnalyzing