Regulatory Network in Protein Phosphorylation
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Substrate: CENPA

Description: Histone H3-like centromeric protein A (Centromere protein A) (CENP-A)(Centromere autoantigen A).

Ensembl ID: ENSG00000115163

UniprotKB/SwissProt: CENPA_HUMAN (P49450)

Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Centromere. Kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CENPA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CENPACENPA_HUMANS7GPRRR S RKPEA 42.73%AurA(STK6) Swiss-Prot 55.0  ViewAnalyzing
2CENPACENPA_HUMANS7GPRRR S RKPEA 42.73%AurB(STK12) Swiss-Prot 55.0  ViewAnalyzing
3CENPACENPA_HUMANS7GPRRR S RKPEA 42.73%AurA Phospho.ELM 7.0  ViewAnalyzing
4CENPACENPA_HUMANS7GPRRR S RKPEA 42.73%AurB HPRD:00313(in vitro)  ViewAnalyzing
5CENPACENPA_HUMANS7GPRRR S RKPEA 42.73%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
6CENPACENPA_HUMANS17APRRR S PSPTP 28.11% Swiss-Prot 55.0 View   
7CENPACENPA_HUMANS19RRRSP S PTPTP 42.52% Swiss-Prot 55.0 View