|Description: Histone H3-like centromeric protein A (Centromere protein A) (CENP-A)(Centromere autoantigen A).|
Ensembl ID: ENSG00000115163
UniprotKB/SwissProt: CENPA_HUMAN (P49450)
Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Centromere. Kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.