Regulatory Network in Protein Phosphorylation
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Substrate: DES

Description: Desmin.

Ensembl ID: ENSG00000175084

UniprotKB/SwissProt: DESM_HUMAN (P17661)

Function: Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DES

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DESDESM_HUMANS12SSQRV S SYRRT 24.68%AurB HPRD:00514(in vitro)  ViewAnalyzing
2DESDESM_HUMANS12SSQRV S SYRRT 24.68%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
3DESDESM_HUMANT17SSYRR T FGGAP 20.03%ROCK_group Phospho.ELM 7.0 ViewAnalyzing
4DESDESM_HUMANT17SSYRR T FGGAP 20.03%ROCK1 HPRD:00514(in vitro)  ViewAnalyzing
5DESDESM_HUMANT17SSYRR T FGGAP 20.03%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
6DESDESM_HUMANS60QVSRT S GGAGG 33.83%AurB(Aurora B) Phospho.ELM 7.0 ViewAnalyzing
7DESDESM_HUMANS60QVSRT S GGAGG 33.83%AurB HPRD:00514(in vitro)  ViewAnalyzing
8DESDESM_HUMANT76ASRLG T TRTPS 20.07%ROCK_group Phospho.ELM 7.0 ViewAnalyzing
9DESDESM_HUMANT76ASRLG T TRTPS 20.07%ROCK1 HPRD:00514(in vitro)  ViewAnalyzing
10DESDESM_HUMANT77SRLGT T RTPSS 30.65%ROCK1 HPRD:00514(in vitro;in vivo)  ViewAnalyzing
11DESDESM_HUMANT77SRLGT T RTPSS 30.65%ROCK_group Phospho.ELM 7.0 ViewAnalyzing