Regulatory Network in Protein Phosphorylation
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Substrate: NTRK1

Description: High affinity nerve growth factor receptor precursor (EC tyrosine kinase receptor type 1) (TRK1-transformingtyrosine kinase protein) (p140-TrkA) (Trk-A).

Synonyms: TRK

Ensembl ID: ENSG00000198400

UniprotKB/SwissProt: NTRK1_HUMAN (P04629)

Function: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Endocytosed to the endosomes upon treatment of cells with NGF (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NTRK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NTRK1NTRK1_HUMANY496IENPQ Y FSDAC 13.30%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
2NTRK1NTRK1_HUMANY496IENPQ Y FSDAC 13.30%TRKA HPRD:01869(in vitro)  ViewAnalyzing
3NTRK1NTRK1_HUMANY496IENPQ Y FSDAC 13.30%TRKA Phospho.ELM 7.0  ViewAnalyzing
4NTRK1NTRK1_HUMANY640AAGMV Y LAGLH 5.07% HPRD:01869(in vitro)View   
5NTRK1NTRK1_HUMANY676MSRDI Y STDYY 15.14%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
6NTRK1NTRK1_HUMANY676MSRDI Y STDYY 15.14% HPRD:01869(in vitro)View   
7NTRK1NTRK1_HUMANY676MSRDI Y STDYY 15.14%TRKA Phospho.ELM 7.0  ViewAnalyzing
8NTRK1NTRK1_HUMANY680IYSTD Y YRVGG 8.02%TRKA Phospho.ELM 7.0  ViewAnalyzing
9NTRK1NTRK1_HUMANY680IYSTD Y YRVGG 8.02% HPRD:01869(in vitro)View   
10NTRK1NTRK1_HUMANY680IYSTD Y YRVGG 8.02%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
11NTRK1NTRK1_HUMANY681YSTDY Y RVGGR 11.13% HPRD:01869(in vitro)View   
12NTRK1NTRK1_HUMANY681YSTDY Y RVGGR 11.13%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
13NTRK1NTRK1_HUMANY681YSTDY Y RVGGR 11.13%TRKA Phospho.ELM 7.0  ViewAnalyzing
14NTRK1NTRK1_HUMANY757CPPEV Y AIMRG 6.69% Phospho.ELM 7.0View   
15NTRK1NTRK1_HUMANY757CPPEV Y AIMRG 6.69% HPRD:01869(in vitro)View   
16NTRK1NTRK1_HUMANY791QAPPV Y LDVLG 11.71%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
17NTRK1NTRK1_HUMANY791QAPPV Y LDVLG 11.71%TRKA Phospho.ELM 7.0  ViewAnalyzing
18NTRK1NTRK1_HUMANY791QAPPV Y LDVLG 11.71%TRKA HPRD:01869(in vitro)  ViewAnalyzing