Regulatory Network in Protein Phosphorylation
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Substrate: NTRK2

Description: BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase)(GP145-TrkB) (Trk-B).

Synonyms: TRKB

Ensembl ID: ENSG00000148053

UniprotKB/SwissProt: NTRK2_HUMAN (Q16620)

Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC- gamma-1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1HCF
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NTRK2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NTRK2NTRK2_HUMANY516IENPQ Y FGITN 12.67%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2NTRK2NTRK2_HUMANY516IENPQ Y FGITN 12.67%TRKB HPRD:02712(in vitro;in vivo)  ViewAnalyzing
3NTRK2NTRK2_HUMANY702MSRDV Y STDYY 15.33%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
4NTRK2NTRK2_HUMANY702MSRDV Y STDYY 15.33%TRKB HPRD:02712(in vitro;in vivo)  ViewAnalyzing
5NTRK2NTRK2_HUMANY706VYSTD Y YRVGG 8.02%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
6NTRK2NTRK2_HUMANY706VYSTD Y YRVGG 8.02%TRKB HPRD:02712(in vitro;in vivo)  ViewAnalyzing
7NTRK2NTRK2_HUMANY707YSTDY Y RVGGH 11.13%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
8NTRK2NTRK2_HUMANY707YSTDY Y RVGGH 11.13%TRKB HPRD:02712(in vitro;in vivo)  ViewAnalyzing
9NTRK2NTRK2_HUMANY817KASPV Y LDILG 11.31%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
10NTRK2NTRK2_HUMANY817KASPV Y LDILG 11.31%TRKB HPRD:02712(in vitro;in vivo)  ViewAnalyzing